AKR1B10 Cancer Research Results

AKR1B10, Aldo-Keto reductase family 1 member B10: Click to Expand ⟱
Source:
Type:

AKR1B10 is a redox/lipid-metabolism associated aldo-keto reductase that is frequently linked to tumor growth, survival, invasion, and therapy resistance, but its role is context-dependent rather than uniformly oncogenic in every cancer. In many cancers—notably lung, liver, pancreatic, and some breast settings—AKR1B10 is upregulated and tends to support malignant behavior by detoxifying reactive carbonyls, protecting membrane lipids, sustaining fatty-acid synthesis/lipid homeostasis, and helping cells tolerate oxidative stress. Those effects can reduce apoptosis and make tumor cells more drug-resistant. A key reason AKR1B10 matters in cancer is that it appears to sit at the intersection of oxidative stress defense, lipid handling, and resistance biology. Recent work also links AKR1B10 to ferroptosis suppression in at least some models, meaning higher AKR1B10 can help cancer cells avoid lipid-peroxidation-driven death; that has been tied to cisplatin resistance in gastric cancer and ferroptosis protection in triple-negative breast cancer models.
Scientific Papers found: Click to Expand⟱
6012- CGA,    Chlorogenic Acid as a Potential Therapeutic Agent for Cholangiocarcinoma
- in-vitro, CCA, HCC9810
TumCP↓, significantly suppressing cell proliferation, migration, colony formation, and invasion while inhibiting the epithelial–mesenchymal transition.
TumCMig↓,
TumCI↓,
EMT↓, CGA Inhibits Migration, Epithelial–Mesenchymal Transition, Invasion, and Colony Formation of RBE Cells
Apoptosis↑, CGA induced apoptosis, modulated cell cycle progression
TumCCA↑,
AKR1B10↓, CGA treatment reduced AKR1B10 expression.
Akt↓, reducing AKR1B10 levels, thereby suppressing AKT activation.
mtDam↑, CGA Promotes Mitochondrial Damage and Apoptosis in RBE Cells
BAX↑, CGA significantly increased the expression levels of bax, caspase9, and caspase3 in the RBE cells while decreasing the expression level of bcl-2
Casp9↑,
Casp3↑,
Bcl-2↓,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

AKR1B10↓, 1,  

Mitochondria & Bioenergetics ⓘ

mtDam↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,  

Migration ⓘ

TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: AKR1B10, Aldo-Keto reductase family 1 member B10
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1467  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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