CBR1 Cancer Research Results

CBR1, carbonyl reductase 1: Click to Expand ⟱
Source:
Type:

CBR1 (carbonyl reductase 1) is an NADPH-dependent enzyme involved in carbonyl compound metabolism, oxidative-stress regulation, and the reduction of several anticancer drugs. In the chemotherapy context, CBR1 can convert anthracyclines such as doxorubicin and daunorubicin into less active alcohol metabolites, including doxorubicinol and daunorubicinol, which may contribute to reduced anticancer potency and increased cardiotoxicity. Therefore, CBR1 inhibition or downregulation may act as a chemosensitizing strategy for anthracycline-treated cancers. However, CBR1 is also reported to suppress invasion and metastasis in some cancers, including gynecologic cancer models, where low CBR1 expression has been associated with poorer prognosis. For database interpretation, CBR1 should be treated as a context-dependent target: downregulation may be beneficial for anthracycline chemosensitization, while loss of CBR1 may be unfavorable in tumors where CBR1 restrains EMT, invasion, or metastasis.



Scientific Papers found: Click to Expand⟱
6135- CHr,    Chrysin as a Multifunctional Therapeutic Flavonoid: Emerging Insights in Pathogenesis Management: A Narrative Review
- Review, Var, NA - Review, AD, NA
Inflam↓, angioG↓, Apoptosis↑, TumAuto↑, TumCCA↑, BioAv↓, Half-Life↓, BioAv↓, *ROS↓, *hepatoP↑, *RenoP↑, TET1↑, MMP9↓, cMyc↓, Ki-67↓, CBR1↓, ROS↑, ChemoSen↑, Bax:Bcl2↑, PUMA↑, NOTCH1↑, *AntiDiabetic↑, *neuroP↑, *GABA↑, *DNAdam↓, *BDNF↑, *memory↑, *AGEs↓, *Aβ↓, *cardioP↑, *AntiArt↑, eff↑, eff↑, *eff↑, RadioS↑, eff↑, ChemoSen↑, eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CBR1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Bax:Bcl2↑, 1,   PUMA↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

NOTCH1↑, 1,  

Migration(tgid=13) ⓘ

Ki-67↓, 1,   MMP9↓, 1,   TET1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   ChemoSen↑, 2,   eff↑, 4,   Half-Life↓, 1,   RadioS↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Ki-67↓, 1,  
Total Targets: 20

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,   GABA↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   cardioP↑, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 1,   RenoP↑, 1,  
Total Targets: 14

Scientific Paper Hit Count for: CBR1, carbonyl reductase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1470  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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