HSPD1 / HSP60 Cancer Research Results

HSPD1 / HSP60, HSPD1 = HSP60 / mitochondrial chaperonin 60: Click to Expand ⟱
Source:
Type:

high HSPD1/HSP60 supports tumor survival, mitochondrial proteostasis, metabolism, apoptosis resistance, invasion, and therapy tolerance. But in some settings, reduced HSPD1 can also worsen tumor behavior, so direction must be considered with cancer type/model.
Scientific Papers found: Click to Expand⟱
6160- Cin,    Cinnamaldehyde induces apoptosis and enhances anti-colorectal cancer activity via covalent binding to HSPD1
- vitro+vivo, CRC, HCT116
AntiTum↑, Apoptosis↑, PI3K↓, Akt↓, TumCG↓, TumCCA↑, HSPD1 / HSP60↓, Ki-67↓, ChemoSen↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

HSPD1 / HSP60↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↓, 1,   TumCG↓, 1,  

Migration ⓘ

Ki-67↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,  

Clinical Biomarkers ⓘ

Ki-67↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HSPD1 / HSP60, HSPD1 = HSP60 / mitochondrial chaperonin 60
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1472  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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