HSPD1 / HSP60 Cancer Research Results

HSPD1 / HSP60, HSPD1 = HSP60 / mitochondrial chaperonin 60: Click to Expand ⟱
Source:
Type:

high HSPD1/HSP60 supports tumor survival, mitochondrial proteostasis, metabolism, apoptosis resistance, invasion, and therapy tolerance. But in some settings, reduced HSPD1 can also worsen tumor behavior, so direction must be considered with cancer type/model.

Field Suggested Entry
Target HSP60 / HSPD1
Full Name Heat shock protein family D member 1
Target Class Mitochondrial chaperonin; heat shock protein
Main Complex HSP60-HSP10 mitochondrial chaperonin complex
Primary Biology Mitochondrial protein folding, mitochondrial proteostasis, oxidative stress response, apoptosis regulation, cellular stress survival
Cancer Relevance Medium-high: HSP60 can support tumor mitochondrial stress tolerance, apoptosis resistance, survival signaling, angiogenesis, and therapy resistance in some cancers
AD Relevance Medium: indirect but plausible relevance through mitochondrial dysfunction, proteotoxic stress, oxidative stress, and neurodegenerative protein-quality-control pathways
Therapeutic Direction Context-dependent. In cancer, inhibition may be useful where tumors are HSP60-dependent. In AD/neurodegeneration, preservation or normalization of HSP60-mediated mitochondrial proteostasis is more likely desirable.


Scientific Papers found: Click to Expand⟱
6518- BCP,    beta-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models
- vitro+vivo, CRC, HCT116
angioG↓, BCP exhibited strong anti-angiogenic activity by blocking the migration of endothelial cells, tube-like network formation, suppression of vascular endothelial growth factor (VEGF)
VEGF↓,
TumVol↓, BCP showed a remarkable reduction in tumor size
HSPD1 / HSP60↓, BCP induced apoptosis through downregulation of HSP60, HTRA, survivin, and XIAP, along with the upregulation of p21 expressions.
HTRA↓,
survivin↓,
XIAP↓,
P21↑,
TumCP↓, BCP Inhibited Proliferation and Migration of HUVECs
TumCMig↓,
TumCG↓, BCP Inhibited Tumor Growth in an HCT-116 Cells Transplanted Mouse Xenograft Mode
Dose↝, BCP was orally administered for a period of 8 weeks. BCP (100 mg/kg) showed a significant anti-tumor activity

6496- BCP,    β-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models
- vitro+vivo, CRC, HCT116 - in-vitro, Nor, HUVECs
angioG↓, BCP exhibited strong anti-angiogenic activity by blocking the migration of endothelial cells, tube-like network formation, suppression of vascular endothelial growth factor (VEGF) secretion from human umbilical vein endothelial cells and sprouting of
VEGF↓,
TumVol↓, BCP showed a remarkable reduction in tumor size and fluorescence molecular tomography signal intensity in all the mice treated with BCP, in a dose-dependent relationship, in ectopic and orthotopic tumor xenograft models, respectively.
Apoptosis↑, BCP induced apoptosis through downregulation of HSP60, HTRA, survivin, and XIAP, along with the upregulation of p21 expressions.
HSPD1 / HSP60↓,
HTRA↓,
survivin↓,
XIAP↓,
P21↑,
*toxicity↓, Notably, it is responsible for the spiciness of black pepper, and has been widely used as a safe food flavoring additive with official approval from the Food and Drug Administration
*neuroP↑, BCP was reported to exert a neuroprotective effect in human neuroblastoma SH-SY5Y cells
*ROS↓, intraperitoneally injected BCP at the dose of 50 mg/kg for one month has successfully attenuated oxidative stress, inhibited inflammatory mediator cyclooxygenase-2 and reduced neuroinflammation
*COX2↓,
*Inflam↓,
*cardioP↑, BCP has been recently shown to exert a remarkable cardioprotective effect against doxorubicin-induced acute cardiotoxicity in albino Wistar rats
AntiCan↑, in vitro studies have suggested that BCP exerts significant anti-cancer effects against different types of cancer cell lines.
ChemoSen↑, BCP potentiated the anti-cancer activity of paclitaxel on human colorectal adenocarcinoma (DLD-1), human breast cancer (MCF-7), and murine fibroblast (L-929) cells.
ROS↑, reported to induce apoptosis of human epidermoid skin cancer cells, mediated by production of reactive oxygen species with loss of mitochondrial membrane potential, as well as alteration of specific apoptotic markers like an increase in Bax/Bcl-2 rat
MMP↑,
Bax:Bcl2↑,
TumCG↓, BCP Inhibited Tumor Growth in an HCT-116 Cells Transplanted Mouse Xenograft Model

6160- Cin,    Cinnamaldehyde induces apoptosis and enhances anti-colorectal cancer activity via covalent binding to HSPD1
- vitro+vivo, CRC, HCT116
AntiTum↑, Herein, we found that cinnamaldehyde (CA) could exert an antitumor effect in HCT-116 cell lines.
Apoptosis↑, CA could induce cell apoptosis by inhibiting the PI3K/Akt signaling pathway and enhanced anti-CRC activity both in vitro and in vivo.
PI3K↓,
Akt↓,
TumCG↓, CA inhibited HCT-116 cells growth
TumCCA↑, CA-induced apoptosis and arrested the G0/G1 phase in HCT-116 cells
HSPD1 / HSP60↓, This study showed that CA could covalently bind with HSPD1 and exert an anti-CRC effect.
Ki-67↓, There was obvious decrease of Ki67-positive cells in “CA” groups
ChemoSen↑, Our results showed that among the anti-CRC chemotherapeutic agents commonly used during clinical practice (TAX, Pt, 5-FU, and OX), the combination of CA and 5-FU exhibited the best synergistic effect in vitro


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

HSPD1 / HSP60↓, 3,   HTRA↓, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1,   XIAP↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 2,   Bax:Bcl2↑, 1,   survivin↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↑, 2,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↓, 1,   TumCG↓, 3,  

Migration(tgid=13) ⓘ

Ki-67↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   VEGF↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 2,   Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   TumVol↓, 2,  
Total Targets: 24

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   Inflam↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   neuroP↑, 1,   toxicity↓, 1,  
Total Targets: 6

Scientific Paper Hit Count for: HSPD1 / HSP60, HSPD1 = HSP60 / mitochondrial chaperonin 60
2 Beta-Caryophyllene
1 Cinnamon
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1472  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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