CCAT1 Cancer Research Results

CCAT1, Colon Cancer Associated Transcript 1: Click to Expand ⟱
Source:
Type:

CCAT1 is a pro-cancer long non-coding RNA (lncRNA) most strongly linked to colorectal cancer. Its main importance is that it can support MYC activation, act as a miRNA sponge, promote proliferation and metastasis, and may contribute to therapy resistance. It is a plausible diagnostic/prognostic biomarker and possible therapeutic RNA target, but it is not yet a standard clinical target.

| Cancer type       | Reported CCAT1 pattern           | Main implication                                                         |
| ----------------- | -------------------------------- | ----------------------------------------- |
| Colorectal cancer | Strongly upregulated             | Tumorigenesis, metastasis, MYC regulation |
| Gastric cancer    | Upregulated in many studies      | Proliferation, invasion, poor prognosis   |
| HCC               | Upregulated                      | Pro-growth / metastatic phenotype         |
| Lung cancer NSCLC | Upregulated                      | Growth, poor prognosis, possible radioresistance|
| Breast cancer     | Often upregulated                | Proliferation, invasion, EMT-related effects|
| Ovarian cancer    | Reported pro-metastatic role     | Proliferation and metastasis              |
| Other cancers     | Reported in multiple tumor types | Usually oncogenic, but context may vary   |


Scientific Papers found: Click to Expand⟱
6321- DRE,    Dandelion root extract suppressed gastric cancer cells proliferation and migration through targeting lncRNA-CCAT1
- in-vitro, GC, NA
CCAT1↓, TumCP↓, TumCMig↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Migration ⓘ

CCAT1↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CCAT1, Colon Cancer Associated Transcript 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1478  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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