CCAT1 Cancer Research Results

CCAT1, Colon Cancer Associated Transcript 1: Click to Expand ⟱

Source:

Type:

CCAT1 is a pro-cancer long non-coding RNA (lncRNA) most strongly linked to colorectal cancer. Its main importance is that it can support MYC activation, act as a miRNA sponge, promote proliferation and metastasis, and may contribute to therapy resistance. It is a plausible diagnostic/prognostic biomarker and possible therapeutic RNA target, but it is not yet a standard clinical target.

| Cancer type       | Reported CCAT1 pattern           | Main implication                                                         |
| ----------------- | -------------------------------- | ----------------------------------------- |
| Colorectal cancer | Strongly upregulated             | Tumorigenesis, metastasis, MYC regulation |
| Gastric cancer    | Upregulated in many studies      | Proliferation, invasion, poor prognosis   |
| HCC               | Upregulated                      | Pro-growth / metastatic phenotype         |
| Lung cancer NSCLC | Upregulated                      | Growth, poor prognosis, possible radioresistance|
| Breast cancer     | Often upregulated                | Proliferation, invasion, EMT-related effects|
| Ovarian cancer    | Reported pro-metastatic role     | Proliferation and metastasis              |
| Other cancers     | Reported in multiple tumor types | Usually oncogenic, but context may vary   |

Scientific Papers found: Click to Expand⟱

6321-

DRE,

Dandelion root extract suppressed gastric cancer cells proliferation and migration through targeting lncRNA-CCAT1

in-vitro,

GC,

CCAT1↓, Here, we showed that the lncRNA colon cancer-associated transcript-1 (CCAT1) was down-regulated in dandelion-treated GC cells.
TumCP↓, downregulation of CCAT1 inhibited proliferation and migration of gastric cells
TumCMig↓,

7551-

HYP,

Hyperoside exhibits anticancer activity in non‑small cell lung cancer cells with T790M mutations by upregulating FoxO1 via CCAT1

vitro+vivo,

NSCLC,

TumCP↓, Hyperoside inhibited the proliferation and induced the apoptosis of T790M‑positive NSCLC cells.
Apoptosis↑,
FOXO1↑, Hyperoside upregulated forkhead box protein O1 (FoxO1) expression and downregulated the level of long non‑coding RNA (lncRNA) colon cancer associated transcript 1 (CCAT1) in T790M‑positive NSCLC cells.
CCAT1↓,
TumCG↓, In the in vivo study, hyperoside inhibited the growth of T790M‑positive NSCLC xenografts.

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FOXO1↑, 1, TumCG↓, 1,

Migration(tgid=13) ⓘ

CCAT1↓, 2, TumCMig↓, 1, TumCP↓, 2,
Total Targets: 6

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: CCAT1, Colon Cancer Associated Transcript 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells