Database Query Results : , , HSP90

HSP90, HSP90: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Heat shock protein 90 (Hsp90) is a molecular chaperone that plays a critical role in the proper folding, stabilization, and function of many proteins, including those involved in cell signaling, cell cycle regulation, and stress responses.
-Hsp90 interacts with a variety of client proteins that are often mutated or overexpressed in cancer. These include oncogenes (like HER2, BRAF, and AKT) and tumor suppressor proteins (like p53).
-Hsp90 is often overexpressed in cancer cells, which can help them survive under stressful conditions, such as those found in the tumor microenvironment. This overexpression is associated with poor prognosis in several types of cancer.
-HSPs, particularly HSP90, are known to stabilize many proteins that drive cancer progression (oncoproteins).
Scientific Papers found: Click to Expand⟱
554- Anamu,    Petiveria alliacea extracts uses multiple mechanisms to inhibit growth of human and mouse tumoral cells
- in-vitro, NA, 769-P
TumCCA↑, HSP70/HSPA5↓, HSP90↓,
1352- And,    Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy
- in-vitro, AML, K562
Apoptosis↑, ROS↑, HSP90↓,
1547- Api,    Apigenin: Molecular Mechanisms and Therapeutic Potential against Cancer Spreading
- Review, NA, NA
angioG↓, EMT↓, CSCs↓, TumCCA↑, Dose∅, ROS↑, MMP↓, Catalase↓, GSH↓, PI3K↓, Akt↓, NF-kB↓, OCT4↓, Nanog↓, SIRT3↓, SIRT6↓, eff↑, eff↑, Cyt‑c↑, Bax:Bcl2↑, p‑GSK‐3β↓, FOXO3↑, p‑STAT3↓, MMP2↓, MMP9↓, COX2↓, MMPs↓, NRF2↓, HDAC↓, Telomerase↓, eff↑, eff↑, eff↑, eff↑, eff↑, XIAP↓, survivin↓, CK2↓, HSP90↓, Hif1a↓, FAK↓, EMT↓,
1358- Ash,    Withaferin A: A Dietary Supplement with Promising Potential as an Anti-Tumor Therapeutic for Cancer Treatment - Pharmacology and Mechanisms
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, TumCP↓, CSCs↓, TumMeta↓, EMT↓, angioG↓, Vim↓, HSP90↓, annexin II↓, m-FAM72A↓, BCR-ABL↓, Mortalin↓, NRF2↓, cMYB↓, ROS↑, ChemoSen↑, eff↑, ChemoSen↑, ChemoSen↑, eff↑, *BioAv↓, ROCK1↓, TumCI↓, Sp1/3/4↓, VEGF↓, Hif1a↓, EGFR↓,
3155- Ash,    Overview of the anticancer activity of withaferin A, an active constituent of the Indian ginseng Withania somnifera
- Review, Var, NA
Half-Life↝, Inflam↓, antiOx↓, angioG↓, ROS↑, BAX↑, Bak↑, E6↓, E7↓, P53↑, Casp3↑, cl‑PARP↑, STAT3↓, eff↑, HSP90↓, TGF-β↓, TNF-α↓, EMT↑, mTOR↓, NOTCH1↓, p‑Akt↓, NF-kB↓, Dose↝,
3156- Ash,    Withaferin A: From ayurvedic folk medicine to preclinical anti-cancer drug
- Review, Var, NA
MAPK↑, p38↑, BAX↑, BIM↑, CHOP↑, ROS↑, DR5↑, Apoptosis↑, Ferroptosis↑, GPx4↓, BioAv↝, HSP90↓, RET↓, E6↓, E7↓, Akt↓, cMET↓, Glycolysis↓, TCA↓, NOTCH1↓, STAT3↓, AP-1↓, PI3K↓, eIF2α↓, HO-1↑, TumCCA↑, CDK1↓, *hepatoP↑, *GSH↑, *NRF2↑, Wnt↓, EMT↓, uPA↓, CSCs↓, Nanog↓, SOX2↓, CD44↓, lactateProd↓, Iron↑, NF-kB↓,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1↓, CycB↓, cycE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
3162- Ash,    Molecular insights into cancer therapeutic effects of the dietary medicinal phytochemical withaferin A
- Review, Var, NA
lipid-P↓, SOD↑, GPx↑, P53↑, Bcl-2↑, E6↓, E7↓, pRB↑, CycB↑, CDC2↑, P21↑, PCNA↓, ALDH1A1↓, Vim↓, Glycolysis↓, cMyc↓, BAX↑, NF-kB↓, Casp3↑, CHOP↑, DR5↑, ERK↓, Wnt↓, β-catenin/ZEB1↓, Akt↓, HSP90↓,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoP↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, eff↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, eff↑,
2016- CAP,    Capsaicin binds the N-terminus of Hsp90, induces lysosomal degradation of Hsp70, and enhances the anti-tumor effects of 17-AAG (Tanespimycin)
HSP90↓, ATPase↓, eff↑, HSP70/HSPA5↓, other↝, NF-kB↓, EGFR↓, CDK4↓, Src↓, VEGF↓, PI3K↓, Akt↓,
2653- Cela,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoP↑, Catalase↑, ROS↑, HSP90↓, Sp1/3/4↓, AMPK↑, P53↑, JNK↑, ER Stress↑, MMP↓, TumCCA↑, TumAuto↑, Hif1a↑, Akt↑, other↓, Prx↓,
1442- Deg,    Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention
- Review, Var, NA
PI3K/Akt↓, IKKα↓, AMP↓, mTOR↓, survivin↓, NF-kB↓, Apoptosis↑, TumCCA↑, toxicity↓, HSP90↓, Casp↑, TumCG↓, p27↑, cycE↓, angioG↓, Hif1a↓, VEGF↓, *toxicity↑,
809- GAR,    High-Throughput Screen of Natural Product Libraries for Hsp90 Inhibitors
- Review, NA, NA
HRI↓, HSP90↓,
2874- HNK,    Suppressing migration and invasion of H1299 lung cancer cells by honokiol through disrupting expression of an HDAC6‐mediated matrix metalloproteinase 9
- in-vitro, Lung, H1299
MMP9↓, α-tubulin↑, TumCI↓, HDAC6↓, HSP90↓, TumCMig↓, EGFR↓,
2876- HNK,    Honokiol from Magnolia spp. induces G1 arrest via disruption of EGFR stability through repressing HDAC6 deacetylated Hsp90 function in lung cancer cells
- in-vitro, Lung, A549 - in-vitro, Lung, H23 - in-vitro, Lung, HCC827
EGFR↓, HSP90↓,
2878- HNK,    Suppressing migration and invasion of H1299 lung cancer cells by honokiol through disrupting expression of an HDAC6-mediated matrix metalloproteinase 9
- in-vitro, Lung, H1299
TumCMig↓, TumCI↓, MMP9↓, α-tubulin↑, HDAC6↓, HSP90↓,
1243- LA,    Lactobacilli Modulate Hypoxia-Inducible Factor (HIF)-1 Regulatory Pathway in Triple Negative Breast Cancer Cell Line
- in-vitro, BC, MDA-MB-231
Hif1a↓, HSP90↓, GLUT1↓, VHL↓, SHARP↑,
2924- LT,    Luteolin selectively kills STAT3 highly activated gastric cancer cells through enhancing the binding of STAT3 to SHP-1
- in-vitro, GC, NA - in-vivo, NA, NA
p‑STAT3↓, STAT3↓, Mcl-1↓, survivin↓, Bcl-xL↓, HSP90↓,
2925- LT,    Luteolin Induces Carcinoma Cell Apoptosis through Binding Hsp90 to Suppress Constitutive Activation of STAT3
- in-vitro, Cerv, HeLa - in-vitro, Nor, HEK293 - in-vitro, BC, MCF-7
HSP90↓, p‑STAT3↓, Apoptosis↑, selectivity↑,
493- MF,    Extremely low-frequency electromagnetic field induces acetylation of heat shock proteins and enhances protein folding
- in-vitro, NA, HEK293 - in-vitro, Liver, AML12
ATP↑, HSP70/HSPA5↓, HSP90↓,
524- MF,    Inhibition of Angiogenesis Mediated by Extremely Low-Frequency Magnetic Fields (ELF-MFs)
- vitro+vivo, PC, MS-1 - vitro+vivo, PC, HUVECs
other↓, TumCP↓, TumCMig↓, VEGFR2↓, TumVol↓, HSP70/HSPA5↓, HSP90↓, TumCCA↑, angioG↓,
3847- MSM,    Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement
- Review, Arthritis, NA
*Inflam↓, *Pain↓, *ROS↓, *antiOx↑, *Dose↝, *Half-Life↝, *NF-kB↓, *IL1↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2↓, *NLRP3↓, *NRF2↑, *STAT↓, *Cartilage↑, *eff↑, *eff↑, *GSH↑, *uricA↓, tumCV↓, TumCCA↑, necrosis↑, Apoptosis↑, VEGF↓, HSP90↓, IGF-1?,
2396- PACs,    PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma
- in-vitro, HCC, HCCLM3 - in-vitro, HCC, SMMC-7721 cell - in-vitro, HCC, Bel-7402 - in-vitro, HCC, HUH7 - in-vitro, HCC, HepG2 - in-vitro, Nor, L02
TumCP↓, TumCCA↓, Apoptosis↑, GlucoseCon↓, lactateProd↓, PKM2↓, Glycolysis↓, HK2↓, PFK↓, OXPHOS↑, ChemoSen↑, HSP90↓, Hif1a↓,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, eff↑, P-gp↓, eff↑, eff↑, eff↑, eff↑, CycB↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
73- QC,    The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3
HSP90↓, Casp3↑, Casp9↑,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1↓, cycA1↓, CycB↓, cycE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 26

Results for Effect on Cancer/Diseased Cells:
ACLY↓,1,   Akt↓,7,   Akt↑,1,   p‑Akt↓,1,   ALDH1A1↓,1,   AMP↓,1,   AMPK↑,2,   angioG↓,5,   annexin II↓,1,   antiOx↓,1,   AP-1↓,2,   Apoptosis↑,9,   ATF3↑,1,   ATF4↑,1,   ATP↑,1,   ATPase↓,1,   Bak↑,1,   BAX↓,1,   BAX↑,3,   Bax:Bcl2↑,1,   Bcl-2↓,2,   Bcl-2↑,1,   Bcl-xL↓,1,   BCR-ABL↓,1,   BIM↑,1,   BioAv↝,1,   Casp↑,1,   Casp3↑,5,   cl‑Casp3↑,1,   Casp7↑,1,   Casp8↑,1,   Casp9↑,2,   cl‑Casp9↑,1,   Catalase↓,1,   Catalase↑,1,   CD44↓,2,   CDC2↓,1,   CDC2↑,1,   CDK1↓,3,   CDK2↓,2,   CDK4↓,5,   CDK6↓,1,   chemoP↑,1,   ChemoSen↑,4,   CHK1↓,1,   Chk2↓,1,   CHOP↑,4,   CK2↓,1,   cMET↓,1,   cMYB↓,1,   cMyc↓,3,   COX2↓,3,   CSCs↓,5,   CXCR4↓,1,   cycA1↓,2,   CycB↓,3,   CycB↑,1,   cycD1↓,1,   cycE↓,3,   Cyt‑c↑,4,   Diablo↑,1,   Dose↝,2,   Dose∅,1,   DR5↑,2,   E-cadherin↑,1,   E6↓,4,   E7↓,4,   eff↑,22,   eff↝,1,   EGFR↓,4,   eIF2α↓,1,   EMT↓,6,   EMT↑,1,   ER Stress↑,2,   ER-α36↓,1,   ERK↓,2,   FAK↓,1,   m-FAM72A↓,1,   Fas↑,1,   FASN↓,1,   Ferroptosis↑,2,   FOXO3↑,3,   GlucoseCon↓,1,   GLUT1↓,1,   Glycolysis↓,3,   GPx↑,1,   GPx4↓,1,   GSH↓,1,   GSH↑,1,   p‑GSK‐3β↓,1,   GSR↑,1,   GSTs↑,1,   H3↑,1,   Half-Life↝,1,   HDAC↓,1,   HDAC6↓,2,   HEY1↓,1,   Hif1a↓,6,   Hif1a↑,1,   HK2↓,1,   HO-1↑,4,   HRI↓,1,   HSP70/HSPA5↓,6,   HSP90↓,26,   IGF-1?,1,   IGF-1↓,1,   IKKα↓,2,   IL12↓,1,   IL1β↓,1,   IL6↓,2,   Inflam↓,1,   Iron↑,1,   JNK↑,2,   KRAS↓,1,   lactateProd↓,2,   LDH↓,1,   LDHA↓,1,   lipid-P↓,1,   lipid-P↑,1,   MAPK↑,2,   Mcl-1↓,2,   MDM2↓,1,   mitResp↓,1,   MMP↓,4,   MMP2↓,3,   MMP9↓,5,   MMPs↓,2,   Mortalin↓,1,   MPO↓,1,   mTOR↓,4,   N-cadherin↓,3,   NADPH↑,1,   Nanog↓,2,   necrosis↑,1,   neuroP↑,1,   NF-kB↓,9,   NOTCH↓,1,   NOTCH1↓,2,   NOTCH3↓,1,   NQO1↑,2,   NRF2↓,2,   NRF2↑,2,   OCT4↓,1,   other↓,2,   other↝,1,   OXPHOS↓,1,   OXPHOS↑,1,   P-gp↓,1,   P21↑,3,   p27↑,1,   p38↑,3,   p50↓,1,   P53↑,5,   PARP↑,1,   cl‑PARP↑,3,   PCNA↓,2,   PDGFR-BB↓,1,   PFK↓,1,   PI3K↓,5,   PI3K/Akt↓,1,   PKCδ↓,1,   PKM2↓,1,   pRB↑,1,   Prx↓,1,   PUMA↑,1,   RadioS↑,1,   RAS↓,1,   p‑RB1↓,1,   RenoP↑,1,   RET↓,1,   ROCK1↓,1,   ROS↓,2,   ROS↑,8,   selectivity↑,2,   SHARP↑,1,   SIRT3↓,1,   SIRT3↑,1,   SIRT6↓,1,   Slug↓,1,   Snail↓,2,   SOD↑,2,   SOX2↓,1,   Sp1/3/4↓,2,   Src↓,1,   STAT3↓,5,   p‑STAT3↓,3,   survivin↓,4,   TCA↓,1,   Telomerase↓,1,   TGF-β↓,1,   TNF-α↓,2,   TOP2↓,1,   toxicity↓,1,   TumAuto↑,2,   TumCCA↓,1,   TumCCA↑,11,   TumCD↑,1,   TumCG↓,1,   TumCI↓,3,   TumCMig↓,3,   TumCP↓,3,   tumCV↓,2,   TumMeta↓,1,   TumVol↓,1,   Twist↓,1,   uPA↓,2,   VCAM-1↓,1,   VEGF↓,6,   VEGFR2↓,1,   VHL↓,1,   Vim↓,4,   Wnt↓,2,   XIAP↓,2,   Zeb1↓,1,   α-tubulin↑,2,   β-catenin/ZEB1↓,4,   γH2AX↑,1,  
Total Targets: 217

Results for Effect on Normal Cells:
AMPK↑,1,   angioG↓,1,   antiOx↑,2,   Aβ↓,1,   BioAv↓,2,   BioAv↝,1,   BP↓,1,   cardioP↑,2,   Cartilage↑,1,   Casp3?,1,   Catalase↑,1,   chemoP↑,1,   COX2↓,2,   Dose↑,1,   Dose↝,1,   eff↑,2,   GSH↑,3,   GSK‐3β↓,1,   Half-Life↑,1,   Half-Life↝,3,   hepatoP↑,1,   HO-1↑,1,   IL1↓,1,   IL10↓,1,   IL17↓,1,   IL18↓,1,   IL1β↓,2,   IL6↓,2,   IL8↓,1,   Inflam↓,2,   iNOS↓,1,   MCP1↓,1,   neuroP↑,1,   NF-kB↓,1,   NLRP3↓,1,   Nrf1↑,1,   NRF2↑,3,   Pain↓,2,   p‑PPARγ↓,1,   Prx↑,1,   ROS↓,2,   SOD↑,1,   SOD2↑,1,   STAT↓,1,   tau↓,1,   TNF-α↓,3,   toxicity↓,1,   toxicity↑,1,   uricA↓,1,  
Total Targets: 49

Scientific Paper Hit Count for: HSP90, HSP90
6 Ashwagandha
3 Honokiol
2 Luteolin
2 Magnetic Fields
2 Quercetin
1 dibenzyl trisulphide(DTS) from Anamu
1 Andrographis
1 Apigenin (mainly Parsley)
1 Capsaicin
1 Celastrol
1 Deguelin
1 Garcinol
1 Lactobacillus
1 Methylsulfonylmethane
1 Proanthocyanidins
1 Sulforaphane (mainly Broccoli)
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:149  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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