P-sel Cancer Research Results

P-sel, P-selectin/SELP/CD62P: Click to Expand ⟱
Source:
Type:

P-selectin: Cell-adhesion molecule / selectin
P-selectin is a strong target because it is biologically actionable and already clinically validated in non-cancer disease. Crizanlizumab is a humanized anti–P-selectin antibody used to reduce vaso-occlusive crises in sickle cell disease, showing that P-selectin can be drugged therapeutically.
-In cancer, P-selectin is highly relevant to platelet-assisted metastasis.

Field Suggested Entry
Target P-selectin / SELP / CD62P
Full Name Selectin P
Target Class Cell-adhesion molecule; selectin family
Main Ligands PSGL-1, sialyl-Lewis X/A-containing glycoproteins, tumor-associated mucins
Primary Biology Platelet adhesion, leukocyte rolling, endothelial activation, thrombosis, inflammation, platelet–tumor cell interaction
Cancer Relevance High: promotes platelet-assisted metastasis, tumor-cell adhesion, immune evasion, vascular arrest, thrombosis, and may serve as a tumor-vascular drug-delivery target
AD Relevance Low-medium: indirect relevance through platelet/endothelial activation, vascular inflammation, and BBB dysfunction; stronger evidence in stroke than AD
Therapeutic Direction Usually inhibit/block pathological P-selectin or P-selectin/PSGL-1 adhesion in metastasis, thrombosis, and vascular inflammation. May also be exploited for targeted drug delivery.


Scientific Papers found: Click to Expand⟱
6475- 1,8-Cin,    1,8-Cineole inhibits platelet-leukocyte aggregate formation by reducing P-selectin expression
- in-vitro, HNSCC, NA
*P-sel↓, Inflam↓, AntiTum↑, AntiAg↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Migration ⓘ

AntiAg↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

P-sel↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: P-sel, P-selectin/SELP/CD62P
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1498  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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