HTRA Cancer Research Results

HTRA, high-temperature requirement A serine proteases: Click to Expand ⟱
Source:
Type:

HTRA1 is a secreted/extracellular serine protease involved in protein quality control, extracellular matrix remodeling, TGF-β-family signaling, and disease-related proteolysis. The human HtrA family has four members, HtrA1–4, and reviews link HtrA dysregulation to cancer, arthritis, neurodegenerative disease, and reproductive disorders.

-most literature supports HTRA1 and HTRA3 as tumor-suppressive, while HTRA2 is more often associated with tumor growth and metastasis.
Field Suggested Entry
Target HTRA1 / HtrA1
Full Name HtrA serine peptidase 1 / high-temperature requirement A serine peptidase 1
Target Class Secreted/extracellular serine protease; HtrA family protease
Primary Biology Extracellular matrix remodeling, protein quality control, TGF-β-family signaling modulation, proteolysis of misfolded or disease-associated proteins
Cancer Relevance Medium and context-dependent: often described as tumor-suppressive through effects on apoptosis, invasion, extracellular matrix, and chemotherapy response, but cancer type matters
AD Relevance Medium-high: implicated in APP/Aβ processing and broader protein-clearance biology; also relevant to vascular/degenerative disease mechanisms
Therapeutic Direction Context-dependent. In AD/protein-aggregation contexts, supporting appropriate HTRA1 protease activity may be beneficial. In cancer, HTRA1 is often tumor-suppressive, so restoration/support may be more logical than inhibition, but tumor-specific annotation is needed.


Scientific Papers found: Click to Expand⟱
6518- BCP,    beta-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models
- vitro+vivo, CRC, HCT116
angioG↓, BCP exhibited strong anti-angiogenic activity by blocking the migration of endothelial cells, tube-like network formation, suppression of vascular endothelial growth factor (VEGF)
VEGF↓,
TumVol↓, BCP showed a remarkable reduction in tumor size
HSPD1 / HSP60↓, BCP induced apoptosis through downregulation of HSP60, HTRA, survivin, and XIAP, along with the upregulation of p21 expressions.
HTRA↓,
survivin↓,
XIAP↓,
P21↑,
TumCP↓, BCP Inhibited Proliferation and Migration of HUVECs
TumCMig↓,
TumCG↓, BCP Inhibited Tumor Growth in an HCT-116 Cells Transplanted Mouse Xenograft Mode
Dose↝, BCP was orally administered for a period of 8 weeks. BCP (100 mg/kg) showed a significant anti-tumor activity

6496- BCP,    β-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models
- vitro+vivo, CRC, HCT116 - in-vitro, Nor, HUVECs
angioG↓, BCP exhibited strong anti-angiogenic activity by blocking the migration of endothelial cells, tube-like network formation, suppression of vascular endothelial growth factor (VEGF) secretion from human umbilical vein endothelial cells and sprouting of
VEGF↓,
TumVol↓, BCP showed a remarkable reduction in tumor size and fluorescence molecular tomography signal intensity in all the mice treated with BCP, in a dose-dependent relationship, in ectopic and orthotopic tumor xenograft models, respectively.
Apoptosis↑, BCP induced apoptosis through downregulation of HSP60, HTRA, survivin, and XIAP, along with the upregulation of p21 expressions.
HSPD1 / HSP60↓,
HTRA↓,
survivin↓,
XIAP↓,
P21↑,
*toxicity↓, Notably, it is responsible for the spiciness of black pepper, and has been widely used as a safe food flavoring additive with official approval from the Food and Drug Administration
*neuroP↑, BCP was reported to exert a neuroprotective effect in human neuroblastoma SH-SY5Y cells
*ROS↓, intraperitoneally injected BCP at the dose of 50 mg/kg for one month has successfully attenuated oxidative stress, inhibited inflammatory mediator cyclooxygenase-2 and reduced neuroinflammation
*COX2↓,
*Inflam↓,
*cardioP↑, BCP has been recently shown to exert a remarkable cardioprotective effect against doxorubicin-induced acute cardiotoxicity in albino Wistar rats
AntiCan↑, in vitro studies have suggested that BCP exerts significant anti-cancer effects against different types of cancer cell lines.
ChemoSen↑, BCP potentiated the anti-cancer activity of paclitaxel on human colorectal adenocarcinoma (DLD-1), human breast cancer (MCF-7), and murine fibroblast (L-929) cells.
ROS↑, reported to induce apoptosis of human epidermoid skin cancer cells, mediated by production of reactive oxygen species with loss of mitochondrial membrane potential, as well as alteration of specific apoptotic markers like an increase in Bax/Bcl-2 rat
MMP↑,
Bax:Bcl2↑,
TumCG↓, BCP Inhibited Tumor Growth in an HCT-116 Cells Transplanted Mouse Xenograft Model


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

HSPD1 / HSP60↓, 2,   HTRA↓, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1,   XIAP↓, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Bax:Bcl2↑, 1,   survivin↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 2,  

Migration(tgid=13) ⓘ

TumCMig↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   VEGF↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   TumVol↓, 2,  
Total Targets: 18

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   Inflam↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   neuroP↑, 1,   toxicity↓, 1,  
Total Targets: 6

Scientific Paper Hit Count for: HTRA, high-temperature requirement A serine proteases
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1501  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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