TK1 Cancer Research Results

TK1, thymidine kinase 1: Click to Expand ⟱

Source:

Type:

<span class="wphighlight">TK1</span> phosphorylates thymidine in the nucleotide salvage pathway, helping produce thymidine nucleotides for DNA synthesis. Its expression rises strongly during S phase, making it a useful indicator of active cell proliferation. Serum <span class="wphighlight">TK1</span> has been investigated for tumor detection, prognosis, treatment monitoring, recurrence and tumor burden. <span class="wphighlight">TK1</span> is more firmly established as a proliferation biomarker than as a routinely drugged therapeutic target.

Scientific Papers found: Click to Expand⟱

6563-

Ger,

5-FU,

Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts

vitro+vivo,

Colon,

SW-620

in-vitro,

Colon,

Caco-2

TS↓, Geraniol (150 microM) but not 5-fluorouracil caused a 2-fold reduction of thymidylate synthase and thymidine kinase expression in cancer cells.
TK1↓,
ChemoSen↑, potentiates 5-fluorouracil efficacy
TumVol↓, combined administration of 5-fluorouracil (20 mg/kg) and geraniol (150 mg/kg) caused a 53% reduction of the tumor volume, whereas a 26% reduction was obtained with geraniol alone, 5-fluorouracil alone showed no effect.
OS↑, when geraniol and 5-FU were administered in combination the survival of mice was increased by 1.5 to 2-fold when compared to controls.

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Functional Outcomes(tgid=23) ⓘ

OS↑, 1, TumVol↓, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: TK1, thymidine kinase 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1503  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

TK1 Cancer Research Results

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis(tgid=4) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Functional Outcomes(tgid=23) ⓘ

Pathway results for Effect on Normal Cells:

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