PHB Cancer Research Results

PHB, prohibitin: Click to Expand ⟱
Source:
Type:

PHB1 and PHB2 form a conserved mitochondrial inner-membrane complex involved in mitochondrial structure, mitochondrial stress signaling, apoptosis, cell-cycle regulation, metabolism, and aging. Recent structural work describes the human prohibitin complex as linked to mitochondrial stress signaling, housekeeping, cell-cycle progression, apoptosis, and lifespan regulation.
Scientific Papers found: Click to Expand⟱
6577- EU,    Eurycomanone suppresses expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28
- in-vitro, Lung, A549
Dose↝, Eurycomanone inhibited A549 lung cancer cell proliferation in a dose-dependent manner at concentrations ranging from 5 to 20 μg/ml.
TumCP↓,
PHB↓, treatment with eurycomanone reduced the abundance expression of the lung cancer markers, heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1, p53 tumor suppressor protein and other cancer-associated genes including prohibitin (PHB), annexin 1 (ANX
ANXA1↓,
p38↓,

6587- EU,    Eurycoma longifolia, A Potential Phytomedicine for the Treatment of Cancer: Evidence of p53-mediated Apoptosis in Cancerous Cells
- in-vitro, Lung, A549 - in-vitro, BC, MCF7
AntiCan↑, Eurycoma longifolia, displayed a strong dose-dependent anticancer efficacy against lung carcinoma (A-549 cells) and breast cancer (MCF-7 cells);
Apoptosis↑, prime mode of cytotoxicity of Eurycoma longifolia and its medicinal compounds is the induction of apoptosis (programmed cell death) via the up-regulation of the expression of p53 (tumor suppressor protein)
P53↑,
BAX↑, and pro-apoptotic protein (Bax) and downregulation of the expression of anti-apoptotic protein (Bcl-2).
Bcl-2↓,
PHB↓, A remarkable alleviation in the mRNA expression of various cancer-associated biomarkers including heterogeneous nuclear ribonucleoprotein (hnRNP), prohibitin (PHB), annexin-1 (ANX1) and endoplasmic reticulum protein-28 (ERp28) has also been evidenced
ANXA1↓,
hnRNPA1↓,


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics(tgid=3) ⓘ

PHB↓, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   p38↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Migration(tgid=13) ⓘ

hnRNPA1↓, 1,   TumCP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ANXA1↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PHB, prohibitin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1505  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

Home Page