MMP15 Cancer Research Results

MMP15, MMP15: Click to Expand ⟱
Source:
Type:

MMP15
Scientific Papers found: Click to Expand⟱
6645- Cen,    Can Asiatic Acid from Centella asiatica Be a Potential Remedy in Cancer Therapy?—A Review
- Review, Var, NA
TumCD↑, It has been demonstrated that AA takes part in inhibiting phosphorylation, inducing cell death, and reducing tumor growth and metastasis by influencing important signaling pathways, such as PI3K, Akt, mTOR, p70S6K, and STAT3, in cancer cells.
TumCG↓,
TumMeta↓,
PI3K↓,
Akt↓,
mTOR↓,
P70S6K↓,
STAT3↓,
N-cadherin↓, igh importance of asiatic acid in reducing the expression of markers such as N-cadherin, β-catenin, claudin-1, and vimentin
β-catenin/ZEB1↓,
CLDN1↓,
Vim↓,
TumAuto↑, potential of asiatic acid to induce autophagy in cancer cells through changes in the levels of specific proteins such as LC3 and p62.
*BioAv↓, limitations related to the pharmacokinetics of AA and its low oral bioavailability.
Casp3↑, AA induces the expression of caspase-3, and in this way, promotes cell death. I
ROS↑, activate the ROS/MAPK signaling pathway to regulate osteosarcoma cell death mechanisms.
MMP15↓, down-regulation of MMP-15 (matrix metalloproteinase-15) [
MMP↓, possible proapoptotic mechanisms of asiatic acid might be related to the fact that it provokes the collapse of mitochondrial membrane potential, leading to a rise in reactive oxidative species (ROS)
eff↑, combining asiatic acid with naringenin (NG).
*toxicity↓, amounts of 2 and 4 g, are also safe and well-tolerated in humans


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Casp3↑, 1,   TumCD↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1,   P70S6K↓, 1,   PI3K↓, 1,   STAT3↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

CLDN1↓, 1,   MMP15↓, 1,   N-cadherin↓, 1,   TumMeta↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  
Total Targets: 18

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 2

Scientific Paper Hit Count for: MMP15, MMP15
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1508  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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