Hypoxia Cancer Research Results

Hypoxia, Hypoxia: Click to Expand ⟱
Source: HalifaxProj(reduce)
Type:
Deprived of adequate oxygen supply at the tissue level.
Hypoxia, a condition characterized by insufficient oxygen levels in tissues.
Cancer cells can adapt to hypoxic conditions through various mechanisms. They may activate hypoxia-inducible factors (HIFs), which are transcription factors that help cells respond to low oxygen levels. HIFs promote the expression of genes involved in angiogenesis (formation of new blood vessels), metabolism, and survival.
Tumors with high levels of hypoxia may be more aggressive and less responsive to treatment.
Scientific Papers found: Click to Expand⟱
6514- BCP,    Effects of β-caryophyllene and oxygen availability on cholesterol and fatty acids in breast cancer cells
- in-vitro, BC, NA
TumCP↓, CB2 / CNR2↓, STAT3↓, mTOR↓, Akt↓, Hypoxia↓,
6695- DFC,    Inhibition of lactate dehydrogenase A by diclofenac sodium induces apoptosis in HeLa cells through activation of AMPK
- in-vitro, Cerv, HeLa
other↝, Glycolysis↓, LDHA↓, Hypoxia↓, Apoptosis↑, lactateProd↓, ATP↓, mt-ROS↑, DNAdam↑, lipid-P↑, AMPK↑, p‑S6K↓, TumCP↓, Dose↝, selectivity↑, i-MDA↑, mtDam↑,
6575- EU,    Eurycomanone from Eurycoma longifolia Jack upregulates neurotrophin-3 gene expression in retinal Müller cells in vitro
- in-vivo, Nor, NA
*Hypoxia↓, *NTF3/NT-3↑, *other↑, *Half-Life↓,
7649- HPT,  Rad,    A pilot study of the effects of mild systemic heating on human head and neck tumour xenografts: Analysis of tumour perfusion, interstitial fluid pressure, hypoxia and efficacy of radiation therapy
- in-vivo, Laryn, FaDu
Dose↝, BloodF↑, Hypoxia↓, RadioS?,
7599- HPT,  Rad,    Recent development on hyperthermia: An effective cotreatment improving radiotherapy outcome
- Review, Var, NA
NA↑, RadioS↑, DNArepair↓, Hypoxia↓, EPR↑, LC↑, OS↑, *toxicity↓, Dose↝, BloodF↑, pH↝, Imm↑, HSP70/HSPA5↑,
7620- HPT,    Hyperthermia and radiotherapy: physiological basis for a synergistic effect
- Review, Var, NA
RadioS↑, DNArepair↓, Hypoxia↓, CSCs↓, Imm↑, pH↝, HSPs↑, ROS↑, eff↑,
7622- HPT,    A Review of the Current Clinical Evidence for Loco-Regional Moderate Hyperthermia in the Adjunct Management of Cancers
- Review, Var, NA
LC↑, OS↑, QoL↑, toxicity↓, Dose↝, Dose↝, ROS↑, DNArepair↓, EPR↑, DNAdam↑, HSP70/HSPA5↑, BloodF↑, Hypoxia↓,
7575- HPT,  Rad,  Chemo,  immuno,    From Localized Mild Hyperthermia to Improved Tumor Oxygenation: Physiological Mechanisms Critically Involved in Oncologic Thermo-Radio-Immunotherapy
RadioS↑, ChemoSen↑, Imm↑, BloodF↑, Hypoxia↓, Dose↝, DNArepair↓, e-pH↓,
7574- HPT,  Oxy,    Improvement of tumor oxygenation by mild hyperthermia
Hypoxia↓, OCR↓, RadioS↑, eff↑, Dose↝,
1175- IVM,  PDT,    Drug induced mitochondria dysfunction to enhance photodynamic therapy of hypoxic tumors
- in-vitro, Var, NA
Hypoxia↓, mitResp↓, ROS↑,

Showing Research Papers: 1 to 10 of 10

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 10

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

LC↑, 2,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

lipid-P↑, 1,   i-MDA↑, 1,   ROS↑, 3,   mt-ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   mitResp↓, 1,   mtDam↑, 1,   OCR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   p‑S6K↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 2,   HSPs↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   DNArepair↓, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   mTOR↓, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

EPR↑, 2,   Hypoxia↓, 9,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↓, 1,   Imm↑, 3,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 2,   e-pH↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   Dose↝, 7,   eff↑, 2,   RadioS?, 1,   RadioS↑, 4,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 4,  

Functional Outcomes(tgid=23) ⓘ

OS↑, 2,   QoL↑, 1,   toxicity↓, 1,  
Total Targets: 42

Pathway results for Effect on Normal Cells:


Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hypoxia↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NTF3/NT-3↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Half-Life↓, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 5

Scientific Paper Hit Count for: Hypoxia, Hypoxia
6 Hyperthermia
3 Radiotherapy/Radiation
1 Beta-Caryophyllene
1 Diclofenac
1 Eurycomanone
1 Chemotherapy
1 immunotherapy
1 Oxygen, Hyperbaric
1 Ivermectin
1 Photodynamic Therapy
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:151  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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