Hypoxia Cancer Research Results

Hypoxia, Hypoxia: Click to Expand ⟱
Source: HalifaxProj(reduce)
Type:
Deprived of adequate oxygen supply at the tissue level.
Hypoxia, a condition characterized by insufficient oxygen levels in tissues.
Cancer cells can adapt to hypoxic conditions through various mechanisms. They may activate hypoxia-inducible factors (HIFs), which are transcription factors that help cells respond to low oxygen levels. HIFs promote the expression of genes involved in angiogenesis (formation of new blood vessels), metabolism, and survival.
Tumors with high levels of hypoxia may be more aggressive and less responsive to treatment.
Scientific Papers found: Click to Expand⟱
6514- BCP,    Effects of β-caryophyllene and oxygen availability on cholesterol and fatty acids in breast cancer cells
- in-vitro, BC, NA
TumCP↓, CB2 / CNR2↓, STAT3↓, mTOR↓, Akt↓, Hypoxia↓,
6695- DFC,    Inhibition of lactate dehydrogenase A by diclofenac sodium induces apoptosis in HeLa cells through activation of AMPK
- in-vitro, Cerv, HeLa
other↝, Glycolysis↓, LDHA↓, Hypoxia↓, Apoptosis↑, lactateProd↓, ATP↓, mt-ROS↑, DNAdam↑, lipid-P↑, AMPK↑, p‑S6K↓, TumCP↓, Dose↝, selectivity↑, i-MDA↑, mtDam↑,
6575- EU,    Eurycomanone from Eurycoma longifolia Jack upregulates neurotrophin-3 gene expression in retinal Müller cells in vitro
- in-vivo, Nor, NA
*Hypoxia↓, *NTF3/NT-3↑, *other↑, *Half-Life↓,
1175- IVM,  PDT,    Drug induced mitochondria dysfunction to enhance photodynamic therapy of hypoxic tumors
- in-vitro, Var, NA
Hypoxia↓, mitResp↓, ROS↑,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

lipid-P↑, 1,   i-MDA↑, 1,   ROS↑, 1,   mt-ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   mitResp↓, 1,   mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   p‑S6K↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hypoxia↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   selectivity↑, 1,  
Total Targets: 23

Pathway results for Effect on Normal Cells:


Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hypoxia↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NTF3/NT-3↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Half-Life↓, 1,  
Total Targets: 4

Scientific Paper Hit Count for: Hypoxia, Hypoxia
1 Beta-Caryophyllene
1 Diclofenac
1 Eurycomanone
1 Ivermectin
1 Photodynamic Therapy
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:151  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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