ADO Cancer Research Results

ADO, Adenosine: Click to Expand ⟱
Source:
Type:

Adenosine (ADO) is a purine nucleoside composed of adenine linked to a ribose sugar. It is chemically distinct from adenosine monophosphate (AMP) and AMP-activated protein kinase (AMPK).

Adenosine functions as both an extracellular signalling molecule and an intracellular metabolic intermediate. Extracellular adenosine activates the G-protein-coupled adenosine receptors A1 (ADORA1), A2A (ADORA2A), A2B (ADORA2B), and A3 (ADORA3). These receptors regulate cyclic AMP signalling, inflammation, immune-cell activity, vascular tone, and cellular proliferation.

Adenosine can also enter cells through equilibrative and concentrative nucleoside transporters, including ENT1/SLC29A1. Intracellular adenosine may be phosphorylated by adenosine kinase to form AMP, potentially increasing AMPK activity during cellular energy stress. Activated AMPK can inhibit mTORC1/S6K signalling, reduce anabolic metabolism, promote autophagy, and suppress cellular proliferation.

In cancer, adenosine can have context-dependent effects. Extracellular adenosine within the tumour microenvironment frequently promotes immunosuppression, particularly through A2A and A2B receptors. In contrast, intracellular adenosine uptake may activate AMPK, inhibit mTORC1 signalling, promote apoptosis, and increase sensitivity to some anticancer agents. Adenosine metabolism, transport, receptor subtype, concentration, and cellular location therefore determine its biological effect.

Several studies have reported that adenosine concentrations are higher in tumor microenvironment than in non-tumor tissue.



Scientific Papers found: Click to Expand⟱
6734- Dipy,  Cisplatin,    Adenosine enhances cisplatin sensitivity in human ovarian cancer cells
- in-vitro, Ovarian, NA
eff↑, eff↓, ADO↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ADO↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↓, 1,   eff↑, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ADO, Adenosine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1525  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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