TLR3 Cancer Research Results

TLR3, Toll-like receptor 3: Click to Expand ⟱
Source:
Type:

TLR3 is an endosomal pattern-recognition receptor that detects double-stranded RNA, including viral RNA and the synthetic agonist poly(I:C). Unlike most Toll-like receptors, it signals through TRIF rather than MyD88, activating pathways such as IRF3/type I interferons, NF-κB, inflammatory cytokines and, in some settings, apoptosis

TLR3 is strongly context-dependent:
  TLR3 activation ↑ can promote tumour-cell apoptosis.
  In other settings, chronic TLR3 signalling can promote inflammation, survival, autophagy, migration or a tumour-supportive microenvironment.


Scientific Papers found: Click to Expand⟱
6824- EMD,    Neuroprotective, Anti-Inflammatory and Antifibrillogenic Offerings by Emodin against Alzheimer’s Dementia: A Systematic Review
- Review, AD, NA
*Inflam?, *antiOx↑, *tau↓, *Aβ↓, *neuroP↑, *ROS↓, *memory↑, *cognitive↑, *other↝, *AChE↓, *BACE↓, *LC3II↓, *Beclin-1↓, *p‑tau↓, *CREB↑, *HNE↓, *BioAv↓, *BioAv↝, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, BioAv↑, *HO-1↑, *PKCδ↑, *Akt↑, *NLRP3↓, *NF-kB↓, *TLR3↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,  
Total Targets: 1

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   HNE↓, 1,   HO-1↑, 1,   ROS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

CREB↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 1,   LC3II↓, 1,  

Migration(tgid=13) ⓘ

PKCδ↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam?, 1,   NF-kB↓, 1,   TLR3↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   tau↓, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE↓, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 4,   BioAv↝, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,   memory↑, 1,   neuroP↑, 1,  
Total Targets: 25

Scientific Paper Hit Count for: TLR3, Toll-like receptor 3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1530  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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