Urea Cancer Research Results

Urea, Urea: Click to Expand ⟱
Source:
Type: Biomarker

Urea is the principal nitrogenous waste product formed in the liver through the urea cycle from ammonia generated during amino-acid metabolism. It is transported in blood and excreted mainly by the kidneys. Urea is a metabolite and clinical biomarker, not a molecular signalling target. Its direction is context-dependent: increased serum urea may indicate renal impairment, dehydration, protein catabolism, or treatment toxicity, while reduced urea may reflect impaired hepatic synthesis, malnutrition, or altered nitrogen metabolism. Reference.



Scientific Papers found: Click to Expand⟱
6885- FA,    Mitigation of renal toxicity induced by paraquat using ferulic acid: Role of inflammatory pathways
- in-vivo, Nor, NA
*Dose↝, *TAC↑, *MDA↓, *RenoP↑, *PI3K↓, *Akt↓, *ROS↓, *Inflam↓, PPARγ↝, *NF-kB↓, *IL6↓, *TNF-α↓, *iNOS↓, *ALAT↓, *AST↓, *Urea↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

PPARγ↝, 1,  
Total Targets: 1

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   MDA↓, 1,   ROS↓, 1,   SOD↑, 1,   TAC↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   iNOS↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   IL6↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

RenoP↑, 1,  
Total Targets: 21

Scientific Paper Hit Count for: Urea, Urea
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1535  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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