miR-199 Cancer Research Results

miR-199, miR-199: Click to Expand ⟱
Source:
Type:

MicroRNA-199 (miR-199) is a family of small non-coding RNAs comprising miR-199a and miR-199b, with mature strands including miR-199a-5p, miR-199a-3p, miR-199b-5p, and miR-199b-3p. These microRNAs regulate gene expression by binding target mRNAs and promoting transcript degradation or translational repression. In many cancers, miR-199 ↓ is the more commonly reported pattern, and restoration or miR-199 ↑ frequently suppresses proliferation, migration, invasion, epithelial-mesenchymal transition, tumour growth, and treatment resistance while promoting apoptosis. Reported downstream targets and pathways include HIF-1α, mTOR/RHEB, YAP1, ITGA3, PAK4/MEK/ERK, KRAS/AKT/ERK, IKKβ/NF-κB, and RGS17. However, miR-199 can have oncogenic effects in selected cancers, so its direction must be recorded according to tumour type, mature strand, specimen, and experimental context. Cancer review; Tumour-suppressive example.



Scientific Papers found: Click to Expand⟱
6972- Form,  PacT,    Formononetin ameliorates the drug resistance of Taxol resistant triple negative breast cancer by inhibiting autophagy
- in-vivo, BC, MDA-MB-231
AntiCan↑, Formononetin (FMNT) has anticancer properties against breast, prostate and colon cancers.
miR-199↓, In MDA-MB-231/Taxol cell line, the role of FMNT was verified to inhibit high miR-199a-3p expression.
ChemoSen↑, combination therapy of FMNT and Taxol was found to be more effective in inhibiting autophagy and drug resistance.
TumVol↓, Oral administration of FMNT reduced tumor volume after MDA-MB-231/Taxol injection in vivo.
Dose↝, FMNT (30 mg/kg) or Taxol (50 mg/mouse) was given orally every three days, and the tumor size was measured every 4 days.
TumCG↓, FMNT inhibits MDA-MB-231/Taxol cell growth
TumCCA↑, FMNT regulates cell cycle and induces apoptosis of MDA-MB-231/Taxol
Apoptosis↑,
TumAuto↓, FMNT inhibits autophagy of MDA-MB-231/Taxol cells
eff↓, combination of FMNT and Taxol was weakened by the addition of rapamycin (100 nM), an inhibitor of mTOR


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

miR-199↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   Dose↝, 1,   eff↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   TumVol↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-199, miR-199
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1543  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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