ABCC2 Cancer Research Results

ABCC2, ABCC2: Click to Expand ⟱
Source:
Type:

ATP-binding cassette subfamily C member 2 (ABCC2; protein name multidrug resistance-associated protein 2, MRP2; also called cMOAT) is an ATP-dependent membrane efflux transporter. It exports organic anions, glutathione, glucuronide and sulfate conjugates, bilirubin conjugates, and several therapeutic drugs from cells. In cancer, ABCC2/MRP2 ↑ is commonly associated with increased drug efflux, reduced intracellular drug accumulation, and chemotherapy resistance. Conversely, ABCC2/MRP2 ↓ or transporter inhibition generally increases intracellular drug exposure and may restore treatment sensitivity. The direction should be interpreted according to the cancer type and whether the administered drug is an ABCC2 substrate. Gene reference; Cancer drug-resistance review.



Scientific Papers found: Click to Expand⟱
6975- Form,    Formononetin inhibits colorectal cancer via the miR-490-3p/ABCC2 axis and synergizes with 5-fluorouracil: mechanistic insights and therapeutic implications
- vitro+vivo, CRC, NA
TumCP↓, results demonstrated that FMNT markedly suppresses CRC proliferation in vitro and tumorigenesis in vivo
MRP↓, FMNT markedly downregulated the MRP2 expression.
miR-490↑, Mechanistically, FMNT upregulated tumor-suppressive miR-490-3p, which directly targets the ABCC2 3'UTR
eff⇅, Notably, overexpression of miR-490-3p augmented FMNT's antitumor effects, whereas inhibition of miR-490-3p diminished its efficacy.
ChemoSen↑, robust synergy between FMNT and 5-FU, with combination therapy achieving superior tumor growth inhibition compared to monotherapies
ABCC2↓, FMNT's antitumor activity and highlight its potential for chemosensitization through ABCC2 inhibition


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ABCC2↓, 1,   miR-490↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MRP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   eff⇅, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ABCC2, ABCC2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1545  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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