AFAP1-AS1 Cancer Research Results

AFAP1-AS1, AFAP1 antisense RNA 1: Click to Expand ⟱
Source:
Type:

AFAP1 antisense RNA 1 (AFAP1-AS1; also called AFAP1AS or AFAP1-AS) is a long non-coding RNA transcribed antisense to the protein-coding AFAP1 locus. AFAP1-AS1 regulates gene expression through mechanisms that can include microRNA sequestration, interaction with regulatory proteins, modulation of mRNA stability, and epigenetic control of transcription. In many solid cancers, AFAP1-AS1 ↑ is the predominant pattern and is associated with increased proliferation, survival, migration, invasion, epithelial-mesenchymal transition, metastasis, treatment resistance, and poorer prognosis. Conversely, AFAP1-AS1 knockdown or expression ↓ commonly reduces tumour-cell growth and motility and can increase apoptosis or treatment sensitivity in experimental models. Reported downstream pathways and targets include c-MYC, WNT/β-catenin, PI3K/AKT, RAS/MEK, EMT-related transcription factors, EZH2-mediated gene repression, and multiple tumour-specific microRNA axes. Gene reference; Cancer review.



Scientific Papers found: Click to Expand⟱
6985- Form,    Formononetin relieves the facilitating effect of lncRNA AFAP1-AS1-miR-195/miR-545 axis on progression and chemo-resistance of triple-negative breast cancer
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549
CDK4↓, Raf↓, miR-195↑, miR-545↑, ChemoSen↑, AFAP1-AS1↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AFAP1-AS1↓, 1,   miR-195↑, 1,   miR-545↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Raf↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: AFAP1-AS1, AFAP1 antisense RNA 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1556  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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