miR-542 Cancer Research Results

miR-542, miR-542: Click to Expand ⟱
Source:
Type:

MicroRNA-542 (miR-542) produces the mature strands miR-542-3p and miR-542-5p, which regulate distinct messenger-RNA targets and should be recorded separately whenever the strand is identified. In many cancers, miR-542-3p ↓ is the predominant reported pattern, and miR-542-3p generally functions as a tumour-suppressive microRNA. Restoration or miR-542-3p ↑ can inhibit cancer-cell proliferation, migration, invasion, epithelial-mesenchymal transition, glycolysis, and tumour growth while promoting apoptosis or cell-cycle arrest. Reported targets and pathways include CDK14, ILK, survivin/BIRC5, PI3K/AKT, WNT/β-catenin, ERK1/2, JAK2, and TGF-β signalling. miR-542-3p can also enhance p53 signalling in susceptible cancer cells. The biological effect remains tumour- and target-dependent, and miR-542-5p must not be assumed to have the same targets or direction as miR-542-3p. Gene reference; Hepatocellular carcinoma study; p53 mechanism study.



Scientific Papers found: Click to Expand⟱
6987- Form,    Formononetin exhibits anticancer activity in gastric carcinoma cell and regulating miR-542-5p
- vitro+vivo, GC, SGC-7901 - in-vitro, BC, MGC803
antiNeop↑, Formononetin exhibits anti‐neoplastic activities in specific types of cancers, such as colon carcinoma and breast cancer.
tumCV↓, formononetin decreased the viability of GC cell line SGC‐7901 and MGC‐803.
TumCMig↓, formononetin suppressed the migration and invasion abilities of GC cells.
TumCI↓,
Dose↝, mice were treated with either 100 μL formononetin (30 mg/kg) or saline (vehicle) using the method of intragastric administration three times a week.
miR-542↓, miR‐542‐5p rather than miR‐1976 and miR‐450b was significantly reduced by formononetin in SGC‐7901 and MGC‐803 cells compared to the untreated control
TumCG↓, miR‐542‐5p inhibitor suppresses GC cells growth and invasion


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

miR-542↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Migration(tgid=13) ⓘ

TumCI↓, 1,   TumCMig↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

antiNeop↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-542, miR-542
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1557  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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