UGDH Cancer Research Results

UGDH, UDP-glucose 6-dehydrogenase: Click to Expand ⟱
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Type:

UGDH (UDP-glucose 6-dehydrogenase) is a cytosolic enzyme that converts UDP-glucose into UDP-glucuronic acid, a precursor required for glucuronidation and for the synthesis of hyaluronan, proteoglycans and other glycosaminoglycans. UGDH is frequently elevated in established cancers, where it can increase extracellular-matrix production, epithelial–mesenchymal transition, tumour-cell migration, invasion, metastasis and resistance to anticancer therapy. UGDH can also promote metastasis through mechanisms extending beyond matrix synthesis, including stabilization of SNAI1 mRNA in lung cancer. Its inhibition or downregulation reduces UDP-glucuronic acid and glycosaminoglycan production and has suppressed tumour growth and metastasis in preclinical models. The typical cancer-associated direction is up, while the desired anticancer modulation is down.



Scientific Papers found: Click to Expand⟱
7044- GA,  QC,    Inhibitory effects of gallic acid and quercetin on UDP-glucose dehydrogenase activity
- in-vitro, BC, MCF7
UGDH↓, UGDH revealed that gallic acid was a non-competitive inhibitor with respect to UDP-glucose and NAD+. I
UGDH↓, In contrast, quercetin showed a competitive inhibition and a mixed-type inhibition with respect to UDP-glucose and NAD+, respectively.
TumCP↓, gallic acid and quercetin are effective inhibitors of UGDH that exert strong antiproliferative activity in breast cancer cells.
Dose↑, The concentrations of gallic acid and quercetin needed to produce effects on UGDH are at least 10-fold higher than can be predicted to be reached under in vivo dietary conditions
*BioAv↓, oral bioavailability of polyphenols including gallic acid and quercetin is very low, producing plasma concentrations most likely only 1/10th to 1/100th of those necessary to produce an effect
eff?, However, it is still not understood if the polyphenols have to be in the free form to exert their activity, or the conjugated polyphenols can exert similar activity, as it has been reported for quercetin


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

UGDH↓, 2,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↑, 1,   eff?, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: UGDH, UDP-glucose 6-dehydrogenase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1569  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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