ASAP2 Cancer Research Results

ASAP2, ArfGAP with SH3 domain, ankyrin repeat and PH domain 2; AMAP2: Click to Expand ⟱
Source:
Type:

ASAP2 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 2; AMAP2) is a multidomain ADP-ribosylation-factor GTPase-activating protein involved in membrane trafficking, actin-cytoskeleton organization, focal-adhesion dynamics and cell migration. In pancreatic ductal adenocarcinoma, ASAP2 can be amplified and overexpressed, and high expression has been associated with poorer prognosis. Experimental ASAP2 disruption reduced pancreatic-cancer-cell migration, supporting a role in tumour invasion and metastasis. In hepatocellular carcinoma, elevated ASAP2 promoted proliferation, migration, invasion, epithelial–mesenchymal transition and lung metastasis, partly by sustaining HGF/c-MET signalling. The typical cancer-associated direction is up, while the desired anticancer modulation is down or functional inhibition.



Scientific Papers found: Click to Expand⟱
7066- GamB,    Unravelling the Therapeutic Potential of Gambogic Acid: Deciphering Its Molecular Mechanism of Action and Emerging Role as an Anticancer Xanthone
- Review, Var, NA
angioG↓, anti-angiogenesis, anti-metastasis, synergistic effects and chemo-sensitization.
TumMeta↓,
ChemoSen↑, GA was reported to increase the intracellular concentration at lower doses of chemotherapeutic drug that helped develop it for combinatorial therapy to exploit its synergistic activity to selectively target cancer cells.
*cardioP↑, biological activities including anticancer, anti- cardiovascular disease (CVD) antiinflammatory, anti-viral, anti-parasitic, anti-infectiousness, antioxidant, and a promising molecule to treat osteoarthritis
*Inflam↓,
*AntiViral↑,
*antiOx↑,
NF-kB↓, suppressing NF-κB activity through modification of 179Cys of IKKβ moieties, resulting decreased expression of TNFα, COX-2, and iNOS
TNF-α↓,
COX2↓,
iNOS↓,
Apoptosis↑, apoptosis, autophagy and suppressing propagation and invasion of cancer cells
TumAuto↑,
TumCP↓,
TumCI↓,
BioAv↓, clinical applications are severely limited due to the poor aqueous solubility (0.013mg/mL) requiring repeat injections.
ROS↑, GA enhances production of reactive oxygen species (ROS) by collapsing the mitochondrial transmembrane potential (MMP), increasing downregulation of SIRT1 in multiple myeloma
MMP↓,
SIRT1↓,
Akt↓, GA inhibits AKT/mTOR complex 1 (mTORC1) by upregulating (AMP-activated protein kinase) AMPK and LRIG1 (leucine-rich repeats and immunoglobulinlike domains 1)
mTORC1↓,
AMPK↑,
LRIG1↑,
ER Stress↑, The inhibition of proteasomal system by GA contributes to the dilation of ER and induces ER stress and mitochondrial membrane depolarization leading to the formation of mega-mitochondria in treated cancer cells.
Paraptosis↑, GA induces paraptosis in cancer cells
Ferroptosis↑, GA induced ferroptosis in HCT116 colon cancer cells was observed
HSP90↓, GA directly inhibits the expression of HSP90, a pleiotropic regulator of multiple signalling pathways, and increases the GSH depletion leading to an increased level of LPOs and ultimately the cell undergoes ferroptosis.
GSH↓,
lipid-P↑,
GPx4↓, figure 4
miR-21↓, GA regimens also decreased the miR-21 expression and blocked PI3K/Akt signaling pathway by enhancing PTEN activity [48].
PI3K↓,
Akt↓,
PTEN↑,
ASAP2↓, GA inhibited the proliferation, migration and invasion by downregulating the expression of ASAP2 and CDK7
CDK7↓,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ASAP2↓, 1,   CDK7↓, 1,   LRIG1↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   lipid-P↑, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   SIRT1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   Apoptosis↑, 1,   Ferroptosis↑, 1,   iNOS↓, 1,   Paraptosis↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-21↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTORC1↓, 1,   PI3K↓, 1,   PTEN↑, 1,  

Migration(tgid=13) ⓘ

TumCI↓, 1,   TumCP↓, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   ChemoSen↑, 1,  
Total Targets: 32

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,  
Total Targets: 4

Scientific Paper Hit Count for: ASAP2, ArfGAP with SH3 domain, ankyrin repeat and PH domain 2; AMAP2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1575  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

Home Page