Stress Cancer Research Results
Stress, Stress: Click to Expand ⟱
Scientific Papers found: Click to Expand⟱
*Dose↝, Subjects ingested 10 g chocolate enriched with 28 mg GABA
*Stress↓, From HRV, those taking GABA chocolate made a quick recovery to the normal state from the stressful state. From these results, GABA chocolate was considered to have a psychological stress-reducing effect.
*memory↑, Several reports have shown that GABA might affect brain protein synthesis, improve many brain functions such as memory and study capability, lower the blood pressure of spontaneously hypertensive rats, and may also have a relaxation effect in humans.
*BP↓,
*Dose↝, Capsules containing 100 mg of GABA or dextrin as a placebo were used as test samples.
*Stress↓, GABA might have alleviated the stress induced by the mental tasks
*BBB↝, While traditional beliefs questioned GABA’s ability to cross the BBB, recent research challenges this notion, proposing specific transporter systems facilitating GABA passage.
*cognitive↑, literature suggests that oral intake of GABA affects the brain illustrated by changes in EEG scans and cognitive performance, with evidence showing that GABA can have beneficial effects for multiple age groups and conditions.
*Dose↝, The gut microbiota is a source of GABA present in the gut, but oral GABA intake needs to be considered as well.
*toxicity↓, A study found that consistent administration of GABA to rats and dogs, even at doses up to 1 g/kg/day, did not exhibit any indications of toxicity
*Stress↓, Another study looked at GABA’s ability to affect brain wave patterns and reported increasing alpha and decreasing beta waves suggesting relaxation
*Inflam↓, The anti-inflammatory activity of GABA-enriched products derived from Lactobacillus fermented rice bran solution exhibited inhibitory effects on the expression of inflammatory enzymes, including inducible nitric oxide synthase and cyclooxygenase-2, a
*iNOS↓,
*COX2/PTGS2↓,
*IL6↓, and reduced the generation of pro-inflammatory cytokines like interleukin (IL)-6, IL-1β, tumor necrosis factor α, and monocyte chemoattractant protein-1
*IL1β↓,
*TNF-α↓,
*Sleep↑, GABA rice containing 26.4 mg of GABA three times daily resulted in the improvement of insomnia scores as assessed by the Kupperman Menopause Index.
*Pain↓, oral GABA supplementation or microbial-derived GABA, as a promising avenue for pain management.
*neuroP↑, potential neuroprotective properties of GABA have garnered significant interest
*eff↑, Specifically, glutamate supplementation was found to enhance memory performance by increasing acetylcholine (ACh) levels, distinguishing its effects from those of GABA
*Ach↑,
*AST↓, In support of the impact of dietary GABA on the CNS, FL50 significantly reduced AST and ALT levels induced by EtOH
*ALAT↓,
*BP↓, revealed a significant reduction in blood pressure within 2 to 4 weeks of FMG intake, and this reduction was sustained throughout the 12-week intervention period.
*other↝, Quantitative analysis of the gut microbiota composition revealed a positive correlation between the abundance of Bacteroides and GABA levels. Individuals with higher concentrations of Bacteroides exhibited elevated GABA levels in the fecal samples,
*other↝, Emerging evidence highlights that oral GABA intake may exert beneficial effects on the brain and psyche through the gut–brain axis.
*Sleep↑, many consumers reporting favorable effects on stress regulation, mood, and sleep, rigorous independent research is still largely lacking.
*Stress↓,
*cognitive↑, Low GABA levels are also considered to play a crucial role in the cognitive symptoms of depression.
*other↝, FMT from old to young rats impaired cognition and reduced brain-derived neurotrophic factor (BDNF) expression [85], whereas FMT from young rats to old rats ameliorated cognition
*other↝, Thus, the consumption of fermented food seems to have beneficial effects on mood [95].
*other↑, Commensal bacteria belonging to Lactobacillus and Bifidobacterium strains have the potential to elevate GABA levels within the ENS
*other↑, Mediterranean diet is also rich in lacto-fermented foods (that is, foods fermented by lactic acid bacteria), such as lacto-fermented pickles, and dairy products, such as yoghurt and cheese [
*memory↑, For instance, in rats, one month of oral GABA supplementation enhanced novel object recognition memory and working memory
*Dose↝, The human body is capable of producing its own GABA. However, factors such as a deficiency in estrogen, zinc, or vitamins, as well as an excess of salicylic acid and food additives, can inhibit the body’s ability to produce GABA
*eff↑, However, when GABA was administered in conjunction with L-arginine, brain GABA levels surged by an impressive 383.3%
*Inflam↓, H2 demonstrates numerous biologically therapeutic properties, including anti-inflammatory, antioxidant, anti-cancer, anti-stress, anti-apoptotic, anti-allergic effects, signaling molecule functions, regulation of redox balance
*antiOx↓,
*Stress↓,
*Dose↝, The administration methods of hydrogen include inhalation, hydrogen-rich water, hydrogen-rich saline, hydrogen-rich eye drops, and hydrogen-rich bathing.
*cardioP↑, graphical abstract and figure 4
*GastroP↑,
*BBB↑, H2 is its ability to easily cross the blood-brain barrier and penetrate biomembranes, diffusing throughout the different tissues and organs.
*eff↑, The above-cited properties led some researchers to refer to it as a "miracle" molecule
*toxicity↓, Regarding the biosafety of hydrogen, numerous reports, including those from the US government and the EU, have indicated that hydrogen is safe for biological systems, showing no acute or chronic toxicity under normal pressure
*Dose↝, human large intestine often produces approximately 70–140 mL of hydrogen daily through the action of coliform bacteria such as Escherichia coli under typical environmental conditions.
*hepatoP↑, including cardioprotective properties, improved liver function, reduced oxidative stress, and prevention of Parkinson's disease
*ROS↓,
*SOD↑, 1.5–2.0 L/day drinking HRW orally 0.55–0.65 mM 1.65–2.6 mg H2/day 8 weeks SOD: ↑ TRABS: ↓ HDL: ↑
*TBARS↓,
*HDL↑,
*LDL↓, figure 4
*Obesity↓, figure 5 obesity
*GSH↑, HRW treatment partially alleviated colitis symptoms, improved histopathological changes, significantly increased glutathione (GSH) concentration, and reduced the level of TNF-α.
*TNF-α↓,
*GutMicro↑, HRW was found to exhibit partial relief of inflammation, oxidative stress, and dysbiosis in the intestinal flora of mice with chronic ulcerative colitis (UC) induced by dextran sulfate sodium (DSS)
*DNAdam↓, HRW-treated mice exhibited decreased levels of markers associated with oxidative DNA damage, such as phosphorylated histone H2AX and 8-hydroxy-2′-deoxyguanosine, as well as markers indicative of aging
*γH2AX↓,
*p‑p38↓, Treatment with HRS also inhibited the activation of p-p38 and NF-κB while suppressing the production of several pro-inflammatory mediators,
*NF-kB↓,
Showing Research Papers: 1 to 5 of 5
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5
Pathway results for Effect on Cancer / Diseased Cells:
Total Targets: 0
Pathway results for Effect on Normal Cells:
NA, unassigned(tgid=0) ⓘ
Stress↓, 5,
Redox & Oxidative Stress(tgid=1) ⓘ
antiOx↓, 1, GSH↑, 1, HDL↑, 1, ROS↓, 1, SOD↑, 1, TBARS↓, 1,
Core Metabolism/Glycolysis(tgid=4) ⓘ
ALAT↓, 1, LDL↓, 1,
Cell Death(tgid=5) ⓘ
iNOS↓, 1, p‑p38↓, 1,
Transcription & Epigenetics(tgid=7) ⓘ
Ach↑, 1, other↑, 2, other↝, 4,
DNA Damage & Repair(tgid=10) ⓘ
DNAdam↓, 1, γH2AX↓, 1,
Barriers & Transport(tgid=15) ⓘ
BBB↑, 1, BBB↝, 1, GastroP↑, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
COX2/PTGS2↓, 1, IL1β↓, 1, IL6↓, 1, Inflam↓, 2, NF-kB↓, 1, TNF-α↓, 2,
Drug Metabolism & Resistance(tgid=21) ⓘ
Dose↝, 6, eff↑, 3,
Clinical Biomarkers(tgid=22) ⓘ
ALAT↓, 1, AST↓, 1, BP↓, 2, GutMicro↑, 1, IL6↓, 1,
Functional Outcomes(tgid=23) ⓘ
cardioP↑, 1, cognitive↑, 2, hepatoP↑, 1, memory↑, 2, neuroP↑, 1, Obesity↓, 1, Pain↓, 1, Sleep↑, 2, toxicity↓, 2,
Total Targets: 41
Scientific Paper Hit Count for: Stress, Stress
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
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