5-HETE Cancer Research Results

5-HETE, 5-hydroxyeicosatetraenoic acid: Click to Expand ⟱
Source:
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5-HETE (5-hydroxyeicosatetraenoic acid; primarily 5(S)-HETE) is an arachidonic-acid-derived eicosanoid produced predominantly through the 5-lipoxygenase (ALOX5/5-LOX) pathway, with 5-HPETE serving as an intermediate. 5-HETE functions as a lipid signaling mediator and can be further metabolized to other bioactive products such as 5-oxo-ETE. In several cancer models, increased 5-LOX pathway activity and 5-HETE production can support tumour-cell proliferation, survival and growth-factor signaling; exogenous 5-HETE has directly stimulated lung-cancer-cell growth, whereas inhibition of 5-LOX reduced proliferation and increased programmed cell death. Thus, in cancer contexts where the ALOX5–5-HETE pathway is activated, the typical disease-associated direction is up and the desired anticancer modulation is generally down. 5-HETE also participates in inflammatory lipid signaling and has been reported at increased levels in Alzheimer’s disease-related inflammatory lipid profiles, although its specific contribution to AD is less established than the broader 5-LOX pathway.



Scientific Papers found: Click to Expand⟱
7142- GI,    Phase II study of the Effects of Ginger Root Extract on Eicosanoids in Colon Mucosa in People at Normal Risk for Colorectal Cancer
- Trial, Nor, NA
COX2/PTGS2↓, Ginger has demonstrated down regulation of COX in vitro and decreased incidence/ multiplicity of adenomas in rats.
*PGE2↓, There was a significant decrease in mean percent change in PGE2 (p=0.05) and 5-HETE (p=0.04), and a trend toward significant decreases in 12-HETE (p=0.09)
*5-HETE↓,
*12-HETE↓,
*Eic↓, it appears that Ginger has the potential to decrease eicosanoid levels, perhaps by inhibiting their synthesis from arachidonic acid.
*AntiCan↑, Ginger’s mechanism of anticarcinogenesis action is not entirely known, but appears to be associated with the anti-oxidant and anti-inflammatory actions of its non-volatile pungent components the gingerols and shogaols.
*antiOx↑,
*Inflam↓,
5LO↓, Ginger inhibits 5-LOX and COX-1 & -2;14, 18–20 decreases inflammation in various murine models
eff↝, Several studies of chemically-induced colon carcinogenesis have demonstrated that ginger is preventive24–26 When ginger was administered in the post-initiation stage, however, it did not suppress aberrant crypt foci formation


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Migration(tgid=13) ⓘ

5LO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↝, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

12-HETE↓, 1,   5-HETE↓, 1,   Eic↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,   PGE2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,  
Total Targets: 7

Scientific Paper Hit Count for: 5-HETE, 5-hydroxyeicosatetraenoic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1586  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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