Eic Cancer Research Results

Eic, eicosanoid levels: Click to Expand ⟱
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Eicosanoid levels refers collectively to concentrations of bioactive lipid mediators derived mainly from arachidonic acid and other polyunsaturated fatty acids, including prostaglandins, thromboxanes, leukotrienes, lipoxins, HETEs and related oxylipins. Eicosanoids regulate inflammation, vascular tone, platelet activity, immune signalling, cell proliferation, migration and tissue repair. In cancer and neurodegenerative disease, total or individual eicosanoid levels may be altered, but the biological meaning is highly dependent on which specific lipid mediators are increased or decreased. Specific mediators such as PGE2, LTB4, 5-HETE or 12-HETE, are more important than the broader eicosanoid-level entry.



Scientific Papers found: Click to Expand⟱
7142- GI,    Phase II study of the Effects of Ginger Root Extract on Eicosanoids in Colon Mucosa in People at Normal Risk for Colorectal Cancer
- Trial, Nor, NA
COX2/PTGS2↓, Ginger has demonstrated down regulation of COX in vitro and decreased incidence/ multiplicity of adenomas in rats.
*PGE2↓, There was a significant decrease in mean percent change in PGE2 (p=0.05) and 5-HETE (p=0.04), and a trend toward significant decreases in 12-HETE (p=0.09)
*5-HETE↓,
*12-HETE↓,
*Eic↓, it appears that Ginger has the potential to decrease eicosanoid levels, perhaps by inhibiting their synthesis from arachidonic acid.
*AntiCan↑, Ginger’s mechanism of anticarcinogenesis action is not entirely known, but appears to be associated with the anti-oxidant and anti-inflammatory actions of its non-volatile pungent components the gingerols and shogaols.
*antiOx↑,
*Inflam↓,
5LO↓, Ginger inhibits 5-LOX and COX-1 & -2;14, 18–20 decreases inflammation in various murine models
eff↝, Several studies of chemically-induced colon carcinogenesis have demonstrated that ginger is preventive24–26 When ginger was administered in the post-initiation stage, however, it did not suppress aberrant crypt foci formation


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Migration(tgid=13) ⓘ

5LO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↝, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

12-HETE↓, 1,   5-HETE↓, 1,   Eic↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,   PGE2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,  
Total Targets: 7

Scientific Paper Hit Count for: Eic, eicosanoid levels
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1588  State#:%  Dir#:1
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