CD47 Cancer Research Results

CD47, cluster of differentiation 47: Click to Expand ⟱
Source:
Type:

CD47 (cluster of differentiation 47; integrin-associated protein, IAP) is a widely expressed transmembrane glycoprotein that regulates cell adhesion, migration and immune recognition. On tumour cells, CD47 binds SIRPα on macrophages and other myeloid cells, activating an inhibitory signal that suppresses phagocytosis and functions as a “don't eat me” immune checkpoint. CD47 is frequently overexpressed in many hematologic and solid malignancies and can promote immune evasion, tumour-cell survival, metastatic progression and resistance to therapy. Blocking the CD47–SIRPα interaction can restore macrophage-mediated phagocytosis and enhance antigen presentation and downstream antitumour immune responses. The typical cancer-associated direction is therefore up, while the desired anticancer modulation is generally down, receptor blockade or disruption of CD47–SIRPα signalling.



Scientific Papers found: Click to Expand⟱
7173- CHA,    Natural compound chaetocin induced DNA damage and apoptosis through reactive oxygen species-dependent pathways in A549 lung cancer cells and in vitro evaluations
- in-vitro, Lung, A549
TumCG↓, TumCCA↑, ROS↑, DNAdam↑, CD47↓, *toxicity↓, MMP↓, Casp3↑, mtDam↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CD47↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,   mtDam↓, 1,  

Cell Death(tgid=5) ⓘ

Casp3↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: CD47, cluster of differentiation 47
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1605  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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