MITF Cancer Research Results

MITF, microphthalmia-associated transcription factor: Click to Expand ⟱
Source:
Type:

MITF (microphthalmia-associated transcription factor) is a lineage-defining transcription factor that regulates melanocyte development, melanogenesis, pigmentation, differentiation, survival and metabolism. In melanoma, MITF can function as a lineage-survival oncogene: increased or amplified MITF supports expression of genes required for proliferation, melanocytic identity and tumour-cell survival. However, MITF activity is highly context-dependent. Relatively high MITF can promote differentiation and proliferation, whereas low MITF states are often associated with dedifferentiation, invasion, therapy resistance and a more stem-like phenotype. Thus, melanoma cells can switch between MITF-high proliferative states and MITF-low invasive states. The cancer-associated direction should therefore be considered context-dependent rather than universally up or down. MITF is separate from downstream melanogenesis targets such as TYR, TYRP1, DCT and melanin production.



Scientific Papers found: Click to Expand⟱
7182- CHA,    Chaetocin inhibits IBMX-induced melanogenesis in B16F10 mouse melanoma cells through activation of ERK
- in-vitro, Melanoma, B16-BL6
Mel↓, tyrosinase↓, MITF↓, ERK↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

Mel↓, 1,   MITF↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 1,   tyrosinase↓, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: MITF, microphthalmia-associated transcription factor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1607  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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