PAF Cancer Research Results

PAF, platelet-activating factor: Click to Expand ⟱
Source:
Type:

Platelet-activating factor (PAF) is a potent bioactive phospholipid mediator involved in inflammation, platelet activation, vascular permeability, leukocyte recruitment, bronchoconstriction and immune signalling. PAF acts primarily through the platelet-activating factor receptor (PTAFR / PAFR), a G-protein-coupled receptor. Excessive PAF signalling can contribute to inflammatory and vascular injury and has also been implicated in tumour-cell proliferation, migration, angiogenesis and metastasis in some cancers. In the nervous system, excessive PAF signalling can promote neuroinflammation, oxidative stress and excitotoxic neuronal injury, although physiological PAF also participates in synaptic signalling. Therefore, pathological PAF activity is generally considered up in inflammatory disease contexts, while the desired modulation is typically down or PAF-receptor antagonism. Ginkgolides, particularly ginkgolide B, are well-characterized antagonists of the PAF receptor and contribute to the pharmacological activity of standardized Ginkgo biloba extracts such as EGb 761.



Scientific Papers found: Click to Expand⟱
7229- EGb 761,    Meta-analysis of the efficacy and safety of Ginkgo biloba extract for the treatment of dementia
- Review, AD, NA
*toxicity↓, Taking a 240-mg daily dose of Ginkgo biloba extract (EGb761) is effective and safe in the treatment of dementia.
*Dose↝, The standard composition of EGb761 preparations is 22.0% to 27.0% flavonoids and 5.0% to 7.0% terpenoids (ginkolides A, B, C; bilobalide; etc.) as active ingredients, and less than 5 ppm of ginkgolic acid,
*ROS↓, Flavonoids inactivate deleterious toxic active oxygen, and terpenoids act as antagonists of platelet activating factor and exert neuroprotection in the brain
*PAF↓,
*memory↑, Ginkgo biloba is thought to improve memory and learning ability, blood flow in the microcirculation, hypoxia tolerance in brain cells, and blood viscosity due to its antioxidant, antiinflammatory, and other activities.
*BloodF↑,
*antiOx↑,
*Inflam↓,
*Tinn↓, Although Ginkgo biloba extract has been reported to be effective in the treatment of vertigo [3], tinnitus [4], headache [5], and anxiety disorders [6] in clinical trials, consistent, conclusive results were not reported because of small sample sizes

7271- GGB,    Ginkgolide B Regulates CDDP Chemoresistance in Oral Cancer via the Platelet-Activating Factor Receptor Pathway
- in-vitro, Oral, NA
PAF↓, we found that ginkgolide B (GB), a specific inhibitor of PAFR, enhanced both CDDP chemosusceptibility and apoptosis.
ChemoSen↑,
Apoptosis↑,

7273- GGB,    Platelet-activating factor induces the stemness of ovarian cancer cells via the PAF/PAFR signaling pathway
- vitro+vivo, Ovarian, NA
PAF↓, These effects could be blocked by PAFR inhibitors. Ginkgolide B (GB) inhibited tumor growth and decreased the CSC percentage in vivo.
CSCs↓, Our results suggest that PAF can regulate the stemness of ovarian cancer cells through the PAF/PAFR pathway, suggesting a new target for the treatment of ovarian cancer.

7217- GGB,    Role of Ginkgolides in the Inflammatory Immune Response of Neurological Diseases: A Review of Current Literatures
- Review, AD, NA
*eff↑, Ginkgolides are one of the important medicinal ingredients in Ginkgo biloba.
*AntiAg↑, ginkgolides have anti-platelet-activating, anti-apoptotic, anti-oxidative, neurotrophic, and neuroimmunomodulatory effects.
*Apoptosis↓,
*antiOx↑,
*Inflam↓, Inflammatory immunomodulation is mediated by inhibition of the mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) signaling pathways.
*MAPK↓,
*NF-kB↓,
*PAF↓, They also inhibit the platelet-activating factor (PAF)-mediated signal transduction to attenuate the inflammatory response.
*TLR1↓, Ginkgolides have inflammatory immunomodulation effects, which are mediated by inhibition of the MAPK and TLR/MyD88/NF-κB signaling pathways.
*MyD88↓,
*BDNF↑, Neurotrophic effect Up-regulates the expression of BDNF.
*ROS↓, Regulates anti-apoptotic protein Suppresses p-SAPK/JNK activation, reactive oxygen species, mitochondrial pro-apoptotic factors, PARP, and cytochrome c release.
*PARP↓,
*Cyt‑c↓,


Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

PAF↓, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

PAF↓, 2,   Tinn↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   ROS↓, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Cyt‑c↓, 1,   MAPK↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PARP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 2,   MyD88↓, 1,   NF-kB↓, 1,   TLR1↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,  

Functional Outcomes(tgid=23) ⓘ

memory↑, 1,   toxicity↓, 1,  
Total Targets: 19

Scientific Paper Hit Count for: PAF, platelet-activating factor
3 Ginkgolide B
1 Ginkgo biloba-EGb 761
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1611  State#:%  Dir#:1
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