miR-223-3p Cancer Research Results

miR-223-3p, miR-223-3p: Click to Expand ⟱
Source:
Type:

miR-223-3p - MicroRNA-223-3p

Function: Regulatory microRNA with important roles in inflammation, myeloid and microglial function, cell proliferation, apoptosis, migration, and immune signaling. Targets include pathways involving NLRP3, STAT3, FOXO proteins, and other regulators of inflammatory and cancer signaling.

Cancer: ↕ Context-dependent. miR-223-3p can function as a tumor suppressor in cancers such as hepatocellular and lung cancer, inhibiting proliferation and promoting apoptosis, but can act oncogenically in other cancers including renal-cell and breast cancer by promoting proliferation, migration, invasion, and metastasis.

Alzheimer's Disease: ↕ Dysregulated. Circulating miR-223 has been reported decreased in AD patients, while increased miR-223-3p activity within microglia can promote inflammatory metabolic reprogramming and M1-like activation. Direction therefore depends on biological compartment and disease context.
Scientific Papers found: Click to Expand⟱
7272- GGB,    Ginkgolide B Inhibits Human Bladder Cancer Cell Migration and Invasion Through MicroRNA-223-3p
- in-vitro, Bladder, NA
Zeb1↓, TumCI↓, miR-223-3p↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

miR-223-3p↓, 1,  

Migration(tgid=13) ⓘ

TumCI↓, 1,   Zeb1↓, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-223-3p, miR-223-3p
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1618  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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