CX43/GJA1 Cancer Research Results

CX43/GJA1, Connexin 43 / Gap Junction Protein Alpha 1: Click to Expand ⟱
Source:
Type:

CX43 - Connexin 43 / Gap Junction Protein Alpha 1

Abbreviation: CX43, GJA1

Type: Gap junction / hemichannel protein

Function: Major connexin protein that forms intercellular gap-junction channels and unopposed hemichannels. CX43 regulates direct cell-to-cell communication, ion and metabolite transfer, calcium signaling, proliferation, differentiation, migration, inflammatory signaling, and interactions between tumor cells and the surrounding stroma.

Cancer: ↕ Context-dependent. CX43 frequently acts as a tumor suppressor during early tumorigenesis by maintaining gap-junction intercellular communication and limiting proliferation. However, CX43 can become pro-tumorigenic during later disease stages by promoting migration, invasion, tumor-stromal communication, survival, and metastatic colonization. Direction therefore depends strongly on cancer type, disease stage, cellular localization, and whether gap-junction, hemichannel, or non-channel functions predominate.

Alzheimer's Disease: ↑ CX43 expression and hemichannel activity are increased in reactive astrocytes associated with amyloid plaques. Excessive CX43 hemichannel opening can promote ATP and glutamate release, abnormal Ca2+ signaling, neuroinflammation, and neuronal injury. CX43 hemichannel inhibition has shown neuroprotective effects in experimental amyloidosis models.
Scientific Papers found: Click to Expand⟱
7321- Gos,    The potential roles of gossypol as anticancer agent: advances and future directions
- Review, Var, NA
other↝, BioAv↑, Bcl-2↓, Casp3↑, Casp9↑, MOMP↑, ROS↑, ATP↓, mtDam↑, Apoptosis↑, hTERT/TERT↓, Akt↓, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, NRF2↓, ARE↓, ICAM-1↓, CX43/GJA1↓, NF-kB↓, TLR4↓, IL6↓, Inflam↓, CUL5↝, CUL1↝, NOXA↑, TumCI↓, TumCMig↓, TumCA↓, FAK↓, MDM2↓, VEGF↓, angioG↓, HLA-I/II↑, Imm↑, Dose↝, Glycolysis↓, OXPHOS↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CUL1↝, 1,   CUL5↝, 1,   CX43/GJA1↓, 1,   HLA-I/II↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ARE↓, 1,   NRF2↓, 1,   OXPHOS↓, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Glycolysis↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,   hTERT/TERT↓, 1,   MDM2↓, 1,   MOMP↑, 1,   NOXA↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   TumAuto↑, 1,  

Migration(tgid=13) ⓘ

FAK↓, 1,   TumCA↓, 1,   TumCI↓, 1,   TumCMig↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ICAM-1↓, 1,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 1,   NF-kB↓, 1,   TLR4↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

hTERT/TERT↓, 1,   IL6↓, 1,  
Total Targets: 39

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CX43/GJA1, Connexin 43 / Gap Junction Protein Alpha 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1621  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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