Ku70/XRCC6 Cancer Research Results

Ku70/XRCC6, X-Ray Repair Cross-Complementing Protein 6: Click to Expand ⟱
Source:
Type:

Ku70 - X-Ray Repair Cross-Complementing Protein 6

Abbreviation: Ku70, XRCC6

Type: DNA double-strand break repair protein / NHEJ component

Function: Ku70 forms a heterodimer with Ku80 (XRCC5) that rapidly binds DNA double-strand break ends and initiates classical non-homologous end joining (NHEJ). The Ku70/Ku80 complex protects broken DNA ends and recruits DNA-PKcs and additional repair proteins required for DNA-end processing and ligation. Ku70 also participates in telomere maintenance, apoptosis regulation, and cellular DNA-damage responses.

Cancer: ↑ Increased Ku70/XRCC6 expression or NHEJ activity can enhance tumor-cell survival following DNA damage and contribute to resistance to radiotherapy and DNA-damaging chemotherapy. High XRCC6 expression has been associated with tumor progression and poorer prognosis in several cancers. However, loss of Ku70-mediated DNA repair can also increase genomic instability and cancer susceptibility, so its role differs between tumor initiation and treatment of established cancers.
Scientific Papers found: Click to Expand⟱
7378- RS,    Reserpine inhibits DNA repair, cell proliferation, invasion and induces apoptosis in oral carcinogenesis via modulation of TGF-β signaling
*antiOx↑, Reserpine is a natural indole alkaloid isolated from Rauwolfia serpentina and has potent antioxidant, antimicrobial, and anti-mutagenic properties.
*AntiBio↑,
TGF-β↓, reserpine inhibits TGF-β dependent Smad2/3/4 phosphorylation, thereby blockage Smad3/Snail activation and Smad2/4 nuclear translocation.
p‑SMAD3↓,
p‑SMAD2↓,
p‑SMAD4↓,
SMAD3↓,
Snail↓,
ERCC1↓, downregulating ERCC1, XPF, Ku70, DNA-PKcs, PCNA, cyclin D1, HIF-1α, IL-6, Mcl-1
ERCC4/XPF↓,
Ku70/XRCC6↓,
PCNA↓,
cycD1/CCND1↓,
Hif1a↓,
IL6↓,
Mcl-1↓,
BAX↑, stimulates Bax, cytochrome C, Apaf-1, caspase-9, caspase-3 and PARP protein expressions.
Cyt‑c↑,
APAF1↑,
Casp9↑,
Casp3↑,
PARP↑,
DNArepair↓, therapeutic potential of reserpine in inhibiting DNA repair, cell proliferation, and invasion
TumCP↓,
TumCI↓,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ERCC4/XPF↓, 1,   Ku70/XRCC6↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ERCC1↓, 1,  

Cell Death(tgid=5) ⓘ

APAF1↑, 1,   BAX↑, 1,   Casp3↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   Mcl-1↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↓, 1,   PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,  

Migration(tgid=13) ⓘ

p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↓, 1,   p‑SMAD4↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TumCI↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  
Total Targets: 24

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  
Total Targets: 2

Scientific Paper Hit Count for: Ku70/XRCC6, X-Ray Repair Cross-Complementing Protein 6
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1632  State#:%  Dir#:1
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