compII Cancer Research Results

compII, Mitochondrial Complex II: Click to Expand ⟱
Source:
Type:

Mitochondrial Complex II - Succinate Dehydrogenase Complex

Abbreviation: Complex II, CII, SDH

Components: SDHA, SDHB, SDHC, SDHD

Type: Mitochondrial electron transport chain complex / TCA cycle enzyme

Function: Mitochondrial Complex II, also known as succinate dehydrogenase (SDH), links the tricarboxylic acid (TCA) cycle with the electron transport chain. It oxidizes succinate to fumarate while transferring electrons through FAD and iron-sulfur centers to ubiquinone. Complex II contributes to mitochondrial respiration, cellular metabolism, reactive oxygen species regulation, and control of intracellular succinate levels.

Cancer: ↕ Context-dependent. Loss or inactivation of SDH/Complex II can promote tumorigenesis through accumulation of the oncometabolite succinate, inhibition of α-ketoglutarate-dependent dioxygenases, epigenetic dysregulation, and stabilization of pseudohypoxic signaling. SDH-deficient tumors include subsets of paraganglioma, pheochromocytoma, gastrointestinal stromal tumor, and renal cell carcinoma. Conversely, increased Complex II activity can support oxidative phosphorylation and tumor-cell metabolism in some cancers.
Scientific Papers found: Click to Expand⟱
188- MFrot,  MF,    Spinning magnetic field patterns that cause oncolysis by oxidative stress in glioma cells
- in-vitro, GBM, GBM115 - in-vitro, GBM, DIPG
ROS↑, both GBM and DIPG cells ROS generated by sOMF
SDH↓, Complex II succinate dehydrogenase
eff↓, antioxidant Trolox reverses the cytotoxic effect of sOMF on glioma cells indicating that ROS play a causal role in producing the effect
RPM↑, we hypothesized that the interaction of weak and intermediate strength magnetic fields with the RPM mechanism in the mitochondrial ETC can perturb the electron transfer process (MEP hypothesis) to generate superoxide.
eff↓, We observed that Helmholtz coil did not produce any significant increase in ROS at 2 and 4 h during stimulation or 2 h poststimulation in GBM and DIPG cells
eff↑, oscillating field alone is not sufficient to induce ROS and that the changing angle of the magnetic field axis is also required to achieve this effect.
eff↝, repeated pulse trains rising to and declining from the peak frequency with intervening pauses are sufficient to achieve near maximum level of increase in ROS
eff↝, One spinning magnet or three spinning magnets generate similar cellular ROS levels and the effect of variation of the stimulus off period.
Casp3↑, caspase 3 activation
eff↝, This indicates that the total amount of energy delivered to cancer cells is clearly not the determinant of the potency of stimulation. Instead, it appears that the longer Toff between stimuli of 750 ms in the 4-h stimulation, as opposed to 250 ms in
SOD↓, critical rise in superoxide in two types of human glioma cells (implies SOD capacity exceeded)
ETC↓, found support for the hypothesis that the sOMF-induced increase in ROS is likely due to perturbation of the electron transfer process in the mitochondrial electron transport chain (ETC)
compII↓, Consistent with this hypothesis we have also found that sOMF inhibits the activity of Complex II succinate dehydrogenase


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

compII↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,   RPM↑, 1,   SOD↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ETC↓, 1,   SDH↓, 1,  

Cell Death(tgid=5) ⓘ

Casp3↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↓, 2,   eff↑, 1,   eff↝, 3,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: compII, Mitochondrial Complex II
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1633  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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