DHODH Cancer Research Results

DHODH, Dihydroorotate Dehydrogenase: Click to Expand ⟱
Source:
Type:

DHODH - Dihydroorotate Dehydrogenase

Type: Mitochondrial enzyme / de novo pyrimidine synthesis enzyme

Function: Inner mitochondrial membrane enzyme that catalyzes the oxidation of dihydroorotate to orotate, a rate-limiting step in de novo pyrimidine nucleotide synthesis. DHODH transfers electrons to coenzyme Q and links pyrimidine synthesis with mitochondrial respiration, redox regulation, proliferation, and cellular metabolic adaptation.

Cancer: ↑ Frequently increased or functionally required in rapidly proliferating cancer cells to maintain pyrimidine nucleotide synthesis and tumor growth. DHODH inhibition can suppress proliferation, induce differentiation, impair mitochondrial metabolism, and enhance cancer-cell susceptibility to ferroptosis and other anticancer therapies.
Scientific Papers found: Click to Expand⟱
7385- IBC,    Fighting cancer by triggering non-canonical mitochondrial permeability transition-driven necrosis through reactive oxygen species induction
- vitro+vivo, Lung, A549 - in-vitro, BC, 4T1
Apoptosis↑, Previous reports demonstrated that isobavachalcone (IBC), a natural chalcone, has anticancer effect by apoptosis induction
necrosis↑, Here, we found that IBC induced regulated necrosis in cancer cells
ROS↑, IBC triggered non-apoptotic cell death in lung and breast cancer cells mediated by reactive oxygen species (ROS)
mtDam↑, IBC caused mitochondrial injury and dysfunction as evidenced by mitochondrial Ca2+ overload, the opening of MPT pore, mitochondrial membrane potential collapse, and structural damages
Ca+2↑,
MPT↑,
MMP↓,
AntiCan↑, In addition, IBC showed an anticancer effect in a 4T1 breast cancer cell-derived allograft mouse model
*AntiBio↑, Isobavachalcone (IBC), a natural chalcone, has anticancer, antimicrobial, anti-inflammatory, antioxidative, and neuroprotective activities
*Inflam↓,
*antiOx↓,
*neuroP↑,
p‑Akt↓, IBC potentially inhibits Akt by reducing Akt phosphorylation in lung cancer cells
DHODH↓, in acute myeloid leukemia cells, IBC directly targets dihydroorotate dehydrogenase (DHODH) to induce apoptosis and differentiation . BC is a potent inhibitor of Akt and DHODH [24,25] and actively regulates MAPKs
Diff↑,
MAPK↑, robust MAPK activation by IBC

7767- IBC,    Isobavachalcone exerts anti-gastric cancer effects by targeting dihydroorotate dehydrogenase to induce ROS release and activating the STING pathway
- vitro+vivo, GC, NA
TumCG↓, IBC significantly suppresses gastric cancer growth both in vitro and in vivo.
ROS↑, Inhibition of DHODH by IBC induces ROS accumulation, mitochondrial membrane remodeling, and activation of the STING pathway, promoting antitumor immune responses.
DHODH↓,
MMP↓,
cGAS–STING↑,
Imm↑, IBC exerts dual antitumor and immunostimulatory effects in gastric cancer by targeting DHODH, inducing mitochondrial damage, and activating the STING pathway, highlighting its promising therapeutic potential in gastric cancer.
mtDam↑,


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

DHODH↓, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 2,   MPT↑, 1,   mtDam↑, 2,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 1,   Apoptosis↑, 1,   MAPK↑, 1,   necrosis↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Imm↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

cGAS–STING↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,  
Total Targets: 4

Scientific Paper Hit Count for: DHODH, Dihydroorotate Dehydrogenase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1634  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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