COL4A3 Cancer Research Results

COL4A3, Collagen Type IV Alpha 3 Chain: Click to Expand ⟱
Source:
Type:

COL4A3 - Collagen Type IV Alpha 3 Chain

Abbreviation: COL4A3, α3(IV) collagen

Type: Extracellular matrix / basement membrane collagen

Function: Structural component of type IV collagen in specialized basement membranes, where COL4A3 associates with COL4A4 and COL4A5. The C-terminal NC1 domain of COL4A3, known as tumstatin, has endogenous anti-angiogenic activity and can inhibit endothelial-cell proliferation and tumor-associated neovascularization.

Cancer: ↓ Loss or reduced COL4A3-associated activity can facilitate tumor progression by disrupting basement-membrane integrity and reducing endogenous anti-angiogenic signaling. The COL4A3-derived tumstatin domain inhibits endothelial proliferation, angiogenesis, and tumor growth, supporting a predominantly tumor-suppressive role.
Scientific Papers found: Click to Expand⟱
7393- Amla,    Emblica officinalis extract induces autophagy and inhibits human ovarian cancer cell proliferation, angiogenesis, growth of mouse xenograft tumors
- vitro+vivo, Ovarian, OVCAR-3 - in-vitro, Ovarian, SW626
TumCP↓, Beclin-1↑, LC3B-II↑, Hif1a↓, Dose↝, TumAuto↑, angioG↓, COL4A3↓, CXCL6/GCP-2↓, TYMP/ECGF1↓, IL1β↓, PDGFRB↓, ChemoSen↑, Dose↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

COL4A3↓, 1,   CXCL6/GCP-2↓, 1,   TYMP/ECGF1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 1,   LC3B-II↑, 1,   TumAuto↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PDGFRB↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   Dose↝, 2,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: COL4A3, Collagen Type IV Alpha 3 Chain
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1636  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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