TYMP/ECGF1 Cancer Research Results

TYMP/ECGF1, Endothelial Cell Growth Factor 1 / Thymidine Phosphorylase: Click to Expand ⟱
Source:
Type:

ECGF1 - Endothelial Cell Growth Factor 1 / Thymidine Phosphorylase

Abbreviation: ECGF1, TYMP, TP, PD-ECGF

Type: Pyrimidine metabolism enzyme / angiogenic factor

Function: Thymidine phosphorylase catalyzes the reversible phosphorolysis of thymidine and deoxyuridine and participates in the pyrimidine nucleoside salvage pathway. The same protein was historically identified as platelet-derived endothelial cell growth factor (PD-ECGF/ECGF1). Its activity can promote endothelial-cell migration, angiogenesis, tumor-cell survival, and resistance to apoptosis.

Cancer: ↑ Frequently increased in tumor cells and the tumor microenvironment. Elevated ECGF1/TYMP can promote angiogenesis, tumor progression, and resistance to apoptosis and has been associated with aggressive disease and poorer prognosis in several malignancies. TYMP also affects fluoropyrimidine chemotherapy by activating drugs such as 5'-deoxy-5-fluorouridine and capecitabine-derived metabolites, making its treatment effect context-dependent.
Scientific Papers found: Click to Expand⟱
7393- Amla,    Emblica officinalis extract induces autophagy and inhibits human ovarian cancer cell proliferation, angiogenesis, growth of mouse xenograft tumors
- vitro+vivo, Ovarian, OVCAR-3 - in-vitro, Ovarian, SW626
TumCP↓, Beclin-1↑, LC3B-II↑, Hif1a↓, Dose↝, TumAuto↑, angioG↓, COL4A3↓, CXCL6/GCP-2↓, TYMP/ECGF1↓, IL1β↓, PDGFRB↓, ChemoSen↑, Dose↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

COL4A3↓, 1,   CXCL6/GCP-2↓, 1,   TYMP/ECGF1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 1,   LC3B-II↑, 1,   TumAuto↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PDGFRB↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   Dose↝, 2,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TYMP/ECGF1, Endothelial Cell Growth Factor 1 / Thymidine Phosphorylase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1638  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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