TYMP/ECGF1 Cancer Research Results

TYMP/ECGF1, Endothelial Cell Growth Factor 1 / Thymidine Phosphorylase: Click to Expand ⟱
Source:
Type:

ECGF1 - Endothelial Cell Growth Factor 1 / Thymidine Phosphorylase

Abbreviation: ECGF1, TYMP, TP, PD-ECGF

Type: Pyrimidine metabolism enzyme / angiogenic factor

Function: Thymidine phosphorylase catalyzes the reversible phosphorolysis of thymidine and deoxyuridine and participates in the pyrimidine nucleoside salvage pathway. The same protein was historically identified as platelet-derived endothelial cell growth factor (PD-ECGF/ECGF1). Its activity can promote endothelial-cell migration, angiogenesis, tumor-cell survival, and resistance to apoptosis.

Cancer: ↑ Frequently increased in tumor cells and the tumor microenvironment. Elevated ECGF1/TYMP can promote angiogenesis, tumor progression, and resistance to apoptosis and has been associated with aggressive disease and poorer prognosis in several malignancies. TYMP also affects fluoropyrimidine chemotherapy by activating drugs such as 5'-deoxy-5-fluorouridine and capecitabine-derived metabolites, making its treatment effect context-dependent.
Scientific Papers found: Click to Expand⟱
7393- Amla,    Emblica officinalis extract induces autophagy and inhibits human ovarian cancer cell proliferation, angiogenesis, growth of mouse xenograft tumors
- vitro+vivo, Ovarian, OVCAR-3 - in-vitro, Ovarian, SW626
TumCP↓, Amla extract (AE) has anti-proliferative effects on OC cells under both in vitro and in vivo conditions.
Beclin-1↑, AE did not induce apoptotic cell death, but did significantly increase the expression of the autophagic proteins beclin1 and LC3B-II under in vitro conditions.
LC3B-II↑,
Hif1a↓, AE also significantly reduced the expression of several angiogenic genes, including hypoxia-inducible factor 1α (HIF-1α) in OVCAR3 cells.
Dose↝, cell proliferation was significantly inhibited at AE concentrations ranging from 300–1000 µg/ml
TumAuto↑, AE induces autophagy in OVCAR3 and SW626 cells
angioG↓, AE inhibits angiogenesis-related genes in OVCAR3 cells
COL4A3↓, The expression of COL4A3, CXCL6, ECGF1, EFNB2, FGF2, IL1β, PDGFB, TNFRSF12A and HIF-1α were reduced to less than 40% of control levels (Figure 5D), with Hif-1α being inhibited to the greatest extent.
CXCL6/GCP-2↓,
TYMP/ECGF1↓,
IL1β↓,
PDGFRB↓,
ChemoSen↑, AE with cisplatin synergistically reduced cell proliferation in OVCAR3 cells
Dose↝, mice were fed orally with 10% sucrose (control) or 10% sucrose with AE (100 mg/kg body wt.) daily.


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

COL4A3↓, 1,   CXCL6/GCP-2↓, 1,   TYMP/ECGF1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 1,   LC3B-II↑, 1,   TumAuto↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PDGFRB↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   Dose↝, 2,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TYMP/ECGF1, Endothelial Cell Growth Factor 1 / Thymidine Phosphorylase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1638  State#:%  Dir#:1
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