QPCT/QC Cancer Research Results

QPCT/QC, glutaminyl-peptide cyclotransferase: Click to Expand ⟱
Source:
Type:

Glutaminyl Cyclase (QC / QPCT) — an enzyme that catalyzes conversion of N-terminal glutamate or glutamine residues into pyroglutamate. In Alzheimer’s disease, QC contributes to formation of pyroglutamate-modified amyloid-β (pE-Aβ), which is relatively aggregation-prone, protease-resistant, and neurotoxic. QC inhibition is therefore being investigated as a strategy to reduce pathogenic pE-Aβ formation.

Typical modulation in Alzheimer’s disease: ↑ QC activity/expression is generally considered detrimental because it can increase formation of pyroglutamate Aβ; therapeutic modulation is ↓ QC/QPCT.

Typical modulation in cancer: Context-dependent. QPCT has emerging roles in tumor biology and immune regulation in selected cancers, but there is not a sufficiently universal cancer-direction relationship to classify it broadly as consistently ↑ or ↓ across malignancies.
Scientific Papers found: Click to Expand⟱
7453- HNK,    Determination of Potential Lead Compound from Magnolia officinalis for Alzheimer's Disease through Pharmacokinetic Prediction, Molecular Docking, Dynamic Simulation, and Experimental Validation
- Study, AD, NA
*BACE↓, *AChE↓, *QPCT/QC↓, *GSK‐3β↓, *toxicity↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

QPCT/QC↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 5

Scientific Paper Hit Count for: QPCT/QC, glutaminyl-peptide cyclotransferase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1642  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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