GFAP Cancer Research Results

GFAP, Glial Fibrillary Acidic Protein: Click to Expand ⟱
Source:
Type: biomarker

GFAP - Glial Fibrillary Acidic Protein

Type: Intermediate filament protein / astrocyte marker / reactive astrogliosis biomarker

Function: GFAP is a type III intermediate filament protein expressed predominantly in astrocytes. It contributes to astrocyte cytoskeletal structure, mechanical stability, cellular remodeling, and responses to central nervous system injury. Increased GFAP expression is widely used as a marker of reactive astrocyte activation and astrogliosis.

Cancer: ↕ Context-dependent. GFAP is widely used as a marker of astrocytic differentiation in gliomas and astrocytomas, but total GFAP expression does not show a uniform relationship with tumor aggressiveness. Changes in GFAP isoforms, particularly the GFAPδ/GFAPα ratio, may be associated with more malignant astrocytoma phenotypes.

Alzheimer's Disease: ↑ Increased GFAP reflects reactive astrogliosis associated with Alzheimer's disease pathology. Elevated GFAP is observed in affected brain regions and increased circulating GFAP is strongly associated with cerebral amyloid pathology and progression toward cognitive impairment.
Scientific Papers found: Click to Expand⟱
7520- CAPE,    Neuroprotective Effect of Caffeic Acid Phenethyl Ester in A Mouse Model of Alzheimer's Disease Involves Nrf2/HO-1 Pathway
- in-vivo, AD, NA
*ROS↓, *NRF2↑, *HO-1↑, *Apoptosis↓, *Inflam↓, *Learn↑, *memory↑, *cognitive↑, *neuroP↑, *p‑GSK‐3β↓, GFAP↓,
7484- H2,    Hydrogen Gas Attenuates Toxic Metabolites and Oxidative Stress-Mediated Signaling to Inhibit Neurodegeneration and Enhance Memory in Alzheimer's Disease Models
- in-vivo, AD, NA
*Dose↝, *cognitive↑, *ROS↓, *Inflam↓, *neuroP↑, *memory↑, *Catalase↑, *TNF-α↓, *Aβ↓, *GABA↓, *H2O2↓, *GFAP↓, *antiOx↑, *NRF2↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

GFAP↓, 1,  
Total Targets: 1

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

GFAP↓, 1,   Learn↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   H2O2↓, 1,   HO-1↑, 1,   NRF2↑, 2,   ROS↓, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑GSK‐3β↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 2,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

GABA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 2,   memory↑, 2,   neuroP↑, 2,  
Total Targets: 18

Scientific Paper Hit Count for: GFAP, Glial Fibrillary Acidic Protein
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1647  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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