NOX1 Cancer Research Results

NOX1, NADPH Oxidase 1: Click to Expand ⟱
Source:
Type:

NOX1 - NADPH Oxidase 1

Type: NADPH oxidase / reactive oxygen species-generating enzyme

Function: NOX1 is a membrane-associated NADPH oxidase that transfers electrons from NADPH to molecular oxygen to generate superoxide and downstream reactive oxygen species. NOX1-derived ROS participate in redox signaling, proliferation, host defense, inflammation, angiogenesis, migration, and cellular stress responses.

Cancer: ↑ Frequently increased or activated, particularly in colorectal and other gastrointestinal cancers. Elevated NOX1-derived ROS can promote RAS/MAPK and Wnt/β-catenin signaling, proliferation, angiogenesis, invasion, genomic instability, and tumor progression.

Alzheimer's Disease: ↑ Increased NOX1 expression has been reported in Alzheimer's disease brain, particularly during earlier disease stages, and may contribute to oxidative stress and neuroinflammatory signaling. Evidence is less extensive than for NOX2.
Scientific Papers found: Click to Expand⟱
7563- HYP,    Hyperoside alleviates macrophages and microglia-mediated neuroinflammation and oxidative stress through activating PI3K/AKT and Nrf2/HO-1 signaling pathway post spinal cord injury
- vitro+vivo, Nor, NA
*Inflam↓, Hyperoside (HYP), a bioactive flavonoid derived from traditional Chinese medicinal herbs, exhibits potent anti-inflammatory and antioxidant properties.
*antiOx↑,
*Dose↝, SCI mice were treated with HYP (10 mg/kg or 50 mg/kg) via intraperitoneal injection
*IL1β↓, HYP treatment significantly reduced the expression of pro-inflammatory mediators (IL-1β, IL-6, TNF-α, iNOS, and COX-2) and oxidative stress-related markers (NOX1, NOX2, and NOX4).
*IL6↓,
*TNF-α↓,
*iNOS↓,
*COX2/PTGS2↓,
*NOX4↓,
*NOX2↓,
*NOX1↓,
*PI3K↑, HYP enhanced the activation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway and upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1)
*Akt↑,
*NRF2↑,
*HO-1↑,
*neuroP↑, our findings demonstrate that HYP confers neuroprotection by alleviating neural tissue damage and facilitating locomotor recovery after SCI


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NOX1↓, 1,   NOX2↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   HO-1↑, 1,   NOX4↓, 1,   NRF2↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,   iNOS↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,  
Total Targets: 17

Scientific Paper Hit Count for: NOX1, NADPH Oxidase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1659  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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