4-OHE1 Cancer Research Results

4-OHE1, 4-Hydroxyestrone: Click to Expand ⟱
Source:
Type:

4-OHE1 - 4-Hydroxyestrone

Abbreviation: 4-OHE1

Type: Catechol estrogen / estrogen metabolite / genotoxicity biomarker

Function: 4-Hydroxyestrone is a catechol estrogen formed primarily by 4-hydroxylation of estrone. It can undergo redox cycling and oxidation to estrogen-3,4-quinones, generating reactive oxygen species and electrophilic metabolites capable of forming depurinating DNA adducts.

Cancer: ↑ Increased 4-OHE1 formation is generally considered an unfavorable estrogen-metabolism pattern because 4-hydroxy catechol estrogens can promote oxidative DNA damage, mutagenic estrogen-quinone adduct formation, and potentially estrogen-associated carcinogenesis.

Direction: ↓ Lower 4-OHE1 formation is generally considered favorable, although clinical interpretation should be based on the overall estrogen-metabolite profile rather than 4-OHE1 alone.
Scientific Papers found: Click to Expand⟱
7604- I3C,    Multifunctional aspects of the action of indole-3-carbinol as an antitumor agent
2/16-OHE1↑, CYP1B1↓, 4-OHE1↓, Apoptosis↑, cycD1/CCND1↓, TumCCA↑, AntiTum↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

2/16-OHE1↑, 1,   4-OHE1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

CYP1B1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: 4-OHE1, 4-Hydroxyestrone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1670  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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