IP6K1 Cancer Research Results

IP6K1, Inositol Hexakisphosphate Kinase 1: Click to Expand ⟱
Source:
Type:

IP6K1 - Inositol Hexakisphosphate Kinase 1

Abbreviation: IP6K1

Type: Inositol phosphate kinase / inositol pyrophosphate synthesis enzyme

Function: IP6K1 phosphorylates inositol hexakisphosphate (IP6) to generate 5-diphosphoinositol pentakisphosphate (5-IP7), a high-energy inositol pyrophosphate signaling molecule. IP6K1 regulates cellular metabolism, cytoskeletal remodeling, migration, vesicular trafficking, gene expression, chromatin regulation, DNA repair, and immune-cell function.

Cancer: ↑ Increased or active IP6K1 signaling can promote cancer-cell migration, invasion, and tumor progression through 5-IP7-dependent regulation of cytoskeletal and focal-adhesion signaling. IP6K1 depletion reduces migration and invasion in experimental cancer models, while genetic loss of IP6K1 can protect against chemically induced carcinogenesis and invasive tumor progression.
Scientific Papers found: Click to Expand⟱
7617- Ins,    miR-125a-5p impairs the metastatic potential in breast cancer via IP6K1 targeting
- in-vitro, BC, NA
PI3K↓, Akt↓, TumMeta↓, miR-125b↝, IP6K1↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

IP6K1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

miR-125b↝, 1,   PI3K↓, 1,  

Migration(tgid=13) ⓘ

TumMeta↓, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: IP6K1, Inositol Hexakisphosphate Kinase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1671  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page