IRes Cancer Research Results

IRes, Insulin Resistance: Click to Expand ⟱
Source:
Type:

Insulin Resistance - Reduced Cellular Responsiveness to Insulin

Type: Metabolic phenotype / insulin-signaling dysfunction

Function: Insulin resistance is a state in which target tissues respond inadequately to insulin, resulting in impaired glucose uptake and altered metabolic signaling. It is commonly associated with compensatory hyperinsulinemia, dysregulated PI3K/AKT signaling, inflammation, oxidative stress, mitochondrial dysfunction, and altered lipid metabolism.

Cancer: ↑ Increased insulin resistance and associated hyperinsulinemia can promote a pro-tumorigenic metabolic environment through enhanced insulin/IGF signaling, inflammation, altered lipid metabolism, and increased growth-factor availability. The strength of this association varies by cancer type.

Alzheimer's Disease: ↑ Increased peripheral and brain insulin resistance is associated with impaired neuronal glucose utilization, synaptic dysfunction, neuroinflammation, oxidative stress, abnormal tau phosphorylation, and altered amyloid processing. Improved insulin sensitivity is generally considered favorable.
Scientific Papers found: Click to Expand⟱
7630- Ins,    Modulation of both Insulin Resistance and Cancer Growth by Inositol
- Review, Var, NA - Review, Diabetic, NA
*IRes↓, number of synthetic and natural insulin sensitizers, including inositol, have been recognized to exert both anti-diabetic as well as anti-cancer properties.
*AntiDiabetic↑,
*glucose↝, beneficial effect of inositol in fostering glucose homeostasis as well as in antagonizing cancer growth.
AntiCan↑,
PI3K↓, NOSITOL INHIBITS THE PI3K/AKT PATHWAY IN CANCER CELLS
Akt↓,
Glycolysis↓, On the contrary, in cancer cells, IPGs and myo-Ins inhibits Akt reducing both glycolysis and glucose entry in the cell, while re-establishing the oxidative degradation of carbohydrates along the TCA.
STK11/LKB1↑, As inositol enhances specifically the LKB1 activity, it is worth noting that the AMPK-related anticancer activities are tightly dependent of that pathway
*FASN↓, Inositol inhibits fatty acids biosynthesis and reduces plasma LDL-cholesterol and non-esterified fatty acids (NEFA) levels [74-76].
*LDL↓,
*FFA/NEFA↓,
*ROS↓, Myo-Ins counteracts oxidative damage in fish exposed to environmental oxidative stress
ROS↑, anti-oxidant effects seem to be contextdependent, given that in cancer cells inositol actually increases free radical production
IGF-1↓, Furthermore, myoIns may likely inhibit IGF-1 release downstream of the induced inhibition

7635- Ins,    The Role of Inositols in Endocrine and Neuroendocrine Tumors
- Review, Thyroid, NA
*Dose↝, Its most phosphorylated form, inositol hexakisphosphate (IP6), is a highly represented component in vegetables, cereals and dried fruit
VEGF↓, IP6 has been shown to play a role in inducing cell apoptosis in several types of cancer in vitro and in vivo [18] and in inhibiting vascular endothelial growth factor (VEGF) secretion from tumor cells, which influences neoangiogenesis
Imm↑, InsP6 and inositol also modulate the immune system and immunosuppression in the tumor microenvironment, increasing killer cell activity
NK cell↑,
eff↑, A synergistic anticancer action of IP6 combined with inositol was observed in animal models of colon and mammary tumor and metastatic fibrosarcoma
PI3K↓, Inositol and some of its phosphate derivatives (such as InsP6) have been demonstrated to reduce PI3K expression and Akt activation in neoplastic cells by inhibiting Akt phosphorylation
Akt↓,
EMT↓, In breast cancer cells, inositol has been demonstrated to induce an EMT reversion through a significant downregulation of PI3K/Akt activity
MAPK↓, Inositol is able to inhibit the MAPK, PI3K/AKT and Wnt/NFKB pathways, both directly and through a reduction in insulin resistance.
Wnt↓,
NF-kB↓,
IRes↓,
*ROS↓, inositol enhances immunity, reduces oxidative stress and the epithelial–mesenchymal transition.
TumVol↓, supplementation with myo-Ins, with the addition of selenium, induces a morphological change in thyroid nodules classified as class I or II (at low and intermediate risk according to ultrasound classification of the AACE/ACE/AME 2016 guidelines [41])
*TSHR↓, Several clinical studies have demonstrated that treatment with myo-Ins plus selenium is able to significantly reduce TSH levels in patients with subclinical hypothyroidism. higher serum TSH are associated with an increased risk of thyroid cancer

7638- Ins,    d-Chiro-Inositol in Clinical Practice: A Perspective from the Experts Group on Inositol in Basic and Clinical Research (EGOI)
- Review, Nor, NA
*Insulin↝, d-Chiro-inositol acts through a variety of mechanisms, acting as an insulin sensitizer, inhibiting the transcription of aromatase, in addition to modulating white adipose tissue/brown adipose tissue transdifferentiation.
*CYP19↓,
*Dose↝, Unlike myo-Ins, which is readily available through the diet, primarily in corns, beans, fruits, and nuts [8], it is near impossible to consume sufficient d-chiro-Ins as only a few foods (e.g., buck wheat, soy-lecithin, carob, and lentils) contain sig
*Dose↝, Therefore, d-chiro-Ins is mainly synthesized in the body from myo-Ins
*other↝, ratio between myo-Ins and d-chiro-Ins:. In the plasma, the ratio is 40:1, while in energy-dependent tissues, such as fat or liver, this drops to 2:1. tissue types that have a highglucose consumption rate, such as the brain, display a ratio of 200:1
*Insulin↓, The combined actions of the above mechanisms result in a reduced insulin requirement, thus decreasing systemic insulin levels
*IRes↓, inositol supplementation has shown great success in counteracting IR in a variety of conditions
*Obesity↓, reported a significant reduction in BMI in patients under 30 years of age and PCOS women, suggesting that inositol may have potential as an adjunct therapy to obesity care
*BioAv↝, In a minority of patients, myo-Ins has been observed to have poor bioavailability and efficacy, leading to the phenomenon of “inositol resistance,” which is associated with patients who are unresponsive to myo-Ins supplementation.

7825- LT,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*neuroP↑, neuroprotective activity of luteolin was also observed in a transgenic Drosophila model.
*OS↑, showed that luteolin extend the life span of Drosophila, enhanced its antioxidative ability, and directly bound to Aβ42 and AChE to inhibit the Aβ aggregation and cholinergic deficits
*antiOx↑,
*Aβ42↓,
*AChE↓,
*Aβ↓,
*IRes↓, It was found that luteolin (50 mg/kg) reduced cerebral insulin resistance and tau hyperphosphorylation in a high fat diet (HFD
*p‑tau↓,
*ROS↓, neuroprotective activity in AD was achieved by inhibition of oxidative stress, apoptosis, neuroinflammation, AChE activity, cerebral insulin resistance, or iron imbalance.
*Apoptosis↓,
*Inflam↓,
*Iron↝,


Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

IRes↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Glycolysis↓, 1,   STK11/LKB1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   MAPK↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   IGF-1↓, 1,   PI3K↓, 2,   Wnt↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Imm↑, 1,   NF-kB↓, 1,   NK cell↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   TumVol↓, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Aβ42↓, 1,   FFA/NEFA↓, 1,   IRes↓, 3,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Iron↝, 1,   ROS↓, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,   Insulin↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

FASN↓, 1,   glucose↝, 1,   LDL↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   Dose↝, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   neuroP↑, 1,   Obesity↓, 1,   OS↑, 1,  
Total Targets: 25

Scientific Paper Hit Count for: IRes, Insulin Resistance
3 Inositol
1 Luteolin
1 Mung Bean Sprouts
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1674  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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