ILK Cancer Research Results

ILK, Integrin-Linked Kinase: Click to Expand ⟱
Source:
Type:

ILK - Integrin-Linked Kinase

Abbreviation: ILK, ILK1

Type: Integrin-associated signaling/scaffold protein / focal adhesion regulator

Function: ILK is an integrin-associated focal adhesion protein that interacts with β-integrins, PINCH, and parvin to regulate cell adhesion, cytoskeletal organization, migration, survival, and signal transduction. ILK influences pathways including AKT, GSK3β, β-catenin, and epithelial-mesenchymal transition signaling.

Cancer: ↑ Frequently increased or functionally activated in cancer. Elevated ILK promotes proliferation, survival, epithelial-mesenchymal transition, migration, invasion, angiogenesis, metastasis, and resistance to anticancer therapy. ILK inhibition or knockdown can suppress tumor growth and invasive behavior in multiple experimental cancer models.
Scientific Papers found: Click to Expand⟱
7691- IP6,    Inositol Hexaphosphate Suppresses Growth and Induces Apoptosis in Prostate Carcinoma Cells in Culture and Nude Mouse Xenograft: PI3K-Akt Pathway as Potential Target
- vitro+vivo, Pca, PC3 - in-vitro, Pca, C4-2B
TumCP↓, Apoptosis↑, Casp3↑, cl‑PARP↑, Akt↓, PI3K↓, p‑GSK‐3β↓, cycD1/CCND1↓, TumVol↓, TumW↓, PCNA↓, angioG↓, CD31/PECAM-1↓, ILK↓, VEGF↓, eNOS↓, Hif1a↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ILK↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 1,   Casp3↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑GSK‐3β↓, 1,   PI3K↓, 1,  

Migration(tgid=13) ⓘ

CD31/PECAM-1↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   eNOS↓, 1,   Hif1a↓, 1,   VEGF↓, 1,  

Functional Outcomes(tgid=23) ⓘ

TumVol↓, 1,   TumW↓, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ILK, Integrin-Linked Kinase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1681  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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