TCF7/TCF1 Cancer Research Results

TCF7/TCF1, T Cell Factor 7: Click to Expand ⟱
Source:
Type:

TCF7 - T Cell Factor 7 / TCF-1

Abbreviation: TCF7, TCF-1, TCF1

Type: Transcription factor / Wnt-pathway effector / T-cell differentiation regulator

Function: TCF7 encodes the transcription factor TCF-1, a major regulator of T-cell development, differentiation, memory, and stemness. In chronically stimulated T cells, TCF7 identifies and helps maintain a stem-like or progenitor-exhausted population capable of self-renewal and differentiation into downstream effector and exhausted T-cell populations.

Cancer: ↑ Favorable in the antitumor immune compartment. High TCF7/TCF-1 expression marks stem-like CD8+ T cells with enhanced persistence, self-renewal, and capacity to respond to immune checkpoint blockade. TCF7-high T-cell populations are associated with improved antitumor immunity and more durable responses to immunotherapy. Interpretation should distinguish expression in immune cells from expression within tumor cells.
Scientific Papers found: Click to Expand⟱
7697- IP6,  Ins,    Combination of Inositol Hexaphosphate and Inositol Inhibits Liver Metastasis of Colorectal Cancer in Mice Through the Wnt/β-Catenin Pathway
- in-vivo, CRC, NA
TumMeta↓, OS↑, TumW↓, Wnt↓, TCF7/TCF1↓, cMyc↓,
7858- isoO,    Isoorientin inhibits epithelial-to-mesenchymal properties and cancer stem-cell-like features in oral squamous cell carcinoma by blocking Wnt/β-catenin/STAT3 axis
- in-vitro, Oral, SCC25
CSCs↓, EMT↓, JAK↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, p‑GSK‐3β↓, TCF7/TCF1↓, LEF1↓, ChemoSen↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

TCF7/TCF1↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   EMT↓, 1,   p‑GSK‐3β↓, 1,   STAT3↓, 1,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

LEF1↓, 1,   TumMeta↓, 1,   β-catenin/ZEB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

JAK↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,  

Functional Outcomes(tgid=23) ⓘ

OS↑, 1,   TumW↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TCF7/TCF1, T Cell Factor 7
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1683  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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