ABCG1 Cancer Research Results

ABCG1, ATP-Binding Cassette Subfamily G Member 1: Click to Expand ⟱
Source:
Type:

ABCG1 - ATP-Binding Cassette Subfamily G Member 1

Type: ATP-binding cassette lipid transporter / cholesterol efflux transporter

Function: ABCG1 is an ATP-dependent membrane transporter that regulates intracellular cholesterol and phospholipid homeostasis, particularly by promoting cholesterol efflux to mature HDL particles. ABCG1 influences membrane lipid composition, lipid-raft signaling, macrophage function, cellular metabolism, and inflammatory responses.

Cancer: ↕ Context-dependent, with a predominantly tumor-promoting pattern in many cancers. Elevated ABCG1 can support cancer-cell survival, stem-like properties, proliferation, chemoresistance, Akt-associated signaling, and tumor-promoting macrophage polarization. However, in some cancer models increased ABCG1-mediated cholesterol efflux depletes cellular cholesterol and suppresses proliferation or promotes apoptosis.

Alzheimer's Disease: ↕ Context-dependent. ABCG1 regulates cholesterol efflux and membrane cholesterol distribution and can influence α-, β-, and γ-secretase activity and Aβ production. Experimental studies report both increased and decreased Aβ following ABCG1 modulation, so a consistent disease-associated direction has not been established.
Scientific Papers found: Click to Expand⟱
7701- IP6,    Inositol hexaphosphate sensitizes hepatocellular carcinoma to oxaliplatin relating inhibition of CCN2-LRP6-β-catenin-ABCG1 signaling pathway
- vitro+vivo, HCC, Hep3B - NA, NA, MHCC-97H
AntiCan↑, We proved that IP6 treatment exhibited independent anticancer effect and synergistic anti-proliferative effects in combination with oxaliplatin in HCC.
ChemoSen↑, ABCG1 was contributed to oxaliplatin resistance, and inhibition of ABCG1 were one of the mechanisms of IP6 treatment on HCC oxaliplatin resistance
LRP6↓, The IP6 treatment exhibited inhibition of CCN2-LRP6-Wnt/β-catenin signaling pathway and downregulation of ABCG1 in HCC cells.
Wnt↓,
β-catenin/ZEB1↓,
CCN2/CTGF↓,
ABCG1↓, The expression of ABCG1 and CCN2 in HCC cells was upregulated by oxaliplatin treatment and inhibited by IP6
TumCP↓, IP6 directly inhibited the ability of proliferation and migration in HCC
TumCMig↓,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ABCG1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

LRP6↓, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

CCN2/CTGF↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   β-catenin/ZEB1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ABCG1, ATP-Binding Cassette Subfamily G Member 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1684  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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