HOTAIR Cancer Research Results

HOTAIR, HOX Transcript Antisense RNA: Click to Expand ⟱
Source:
Type:

HOTAIR - HOX Transcript Antisense RNA

Type: Long non-coding RNA / epigenetic regulator

Function: HOTAIR is a trans-acting long non-coding RNA transcribed from the HOXC locus. It regulates gene expression and chromatin organization through interactions with epigenetic regulators including PRC2/EZH2 and LSD1 and can also modulate microRNAs, transcription factors, protein stability, and intracellular signaling pathways.

Cancer: ↑ Frequently overexpressed in human cancers. Elevated HOTAIR promotes proliferation, survival, epithelial-mesenchymal transition, migration, invasion, metastasis, cancer stem-like properties, and resistance to anticancer therapy. High HOTAIR expression is commonly associated with aggressive disease and poorer prognosis.
Scientific Papers found: Click to Expand⟱
7733- isoFl,    Soy-derived isoflavones as chemo-preventive agents targeting multiple signalling pathways for cancer prevention and therapy
- Review, Var, NA
chemoPv↑, The chemopreventive and chemotherapeutic properties of soy and soy-derived compounds, especially isoflavones, have been extensively studied in recent years.
HOTAIR↓, soy-derived isoflavones act as, among other things, potent modulators of HOX transcript antisense RNA (HOTAIR)/SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1),
VEGF↓, vascular endothelial growth factor (VEGF)/C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor type 4 (CXCR4),
CXCL12↓,
CXCR4↓,
ER-α36↝, 17-β-oestradiol (E2)/oestrogen receptor-α (ERα)/neuroglobin (NGB) and sonic hedgehog signalling pathways, epigenetic modulatory agents (i.a. miR-155, miR-34a and miR-10a-5p)
Shh↓,
miR-155↝,
miR-34a↝,
miR-10a-5p↝,
CSCs↓, and cancer stem cells and epithelial-to-mesenchymal transition inhibitors.
EMT↓,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

HOTAIR↓, 1,   miR-10a-5p↝, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   EMT↓, 1,   miR-34a↝, 1,   Shh↓, 1,  

Migration(tgid=13) ⓘ

CXCL12↓, 1,   ER-α36↝, 1,   miR-155↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CXCR4↓, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoPv↑, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HOTAIR, HOX Transcript Antisense RNA
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1685  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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