FGFR4/CD334 Cancer Research Results

FGFR4/CD334, Fibroblast Growth Factor Receptor 4: Click to Expand ⟱
Source:
Type:

FGFR4 - Fibroblast Growth Factor Receptor 4

Abbreviation: FGFR4, CD334

Type: Receptor tyrosine kinase / fibroblast growth factor receptor

Function: FGFR4 is a transmembrane receptor tyrosine kinase that binds fibroblast growth factors and regulates cell proliferation, survival, differentiation, metabolism, and tissue homeostasis. In the liver, FGFR4 forms an important signaling complex with FGF19 and the co-receptor β-Klotho (KLB), regulating bile-acid synthesis and metabolic homeostasis. Activated FGFR4 can signal through pathways including RAS/RAF/MEK/ERK, PI3K/AKT, JAK/STAT3, and GSK3β/β-catenin.

Cancer: ↑ Frequently overexpressed or aberrantly activated in selected cancers, particularly hepatocellular carcinoma. Activation of the FGF19-FGFR4 signaling axis promotes tumor-cell proliferation, survival, resistance to apoptosis, invasion, and treatment resistance. FGF19 amplification or overexpression can create an FGFR4-dependent tumor phenotype, making FGFR4 a therapeutic target for selective kinase inhibitors.
Scientific Papers found: Click to Expand⟱
7745- ISL,    Isoliquiritigenin inhibits colorectal cancer progression by targeting the FGFR4/FASN mediated lipid metabolism pathway
- in-vitro, CRC, NA
AntiCan↑, TumCP↓, TumCMig↓, FASN↓, FGFR4/CD334↓, PI3K↓, Akt↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

FGFR4/CD334↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

FASN↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↓, 1,  

Migration(tgid=13) ⓘ

TumCMig↓, 1,   TumCP↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: FGFR4/CD334, Fibroblast Growth Factor Receptor 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1687  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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