CYP4A/CYP4A11/CYP4A22 Cancer Research Results

CYP4A/CYP4A11/CYP4A22, Cytochrome P450 Family 4 Subfamily A: Click to Expand ⟱
Source:
Type:

CYP4A - Cytochrome P450 Family 4 Subfamily A

Human Members: CYP4A11, CYP4A22

Type: Cytochrome P450 monooxygenase subfamily / fatty-acid ω-hydroxylases

Function: CYP4A enzymes catalyze ω-hydroxylation of fatty acids and participate in the metabolism of arachidonic acid and other lipids. CYP4A-dependent arachidonic-acid metabolism contributes to production of 20-hydroxyeicosatetraenoic acid (20-HETE), a bioactive lipid mediator involved in vascular regulation, inflammation, cellular proliferation, and angiogenic signaling. In humans, CYP4A11 is an important CYP4A enzyme involved in 20-HETE synthesis, while CYP4A22 is a closely related family member.

Cancer: ↑ Increased CYP4A/20-HETE pathway activity is generally associated with tumor-promoting effects. CYP4A-derived 20-HETE can stimulate cancer-cell proliferation, survival, angiogenesis, migration, and tumor growth. CYP4A/4F expression is elevated in several tumor types, and pharmacological inhibition of 20-HETE-producing CYP enzymes suppresses growth in multiple experimental cancer models.
Scientific Papers found: Click to Expand⟱
7749- ISL,    Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1
- in-vitro, GBM, U87MG
angioG↓, COX2/PTGS2↓, mPGES-1↓, CYP4A/CYP4A11/CYP4A22↓, FGF21↓, TGF-β↓, VEGF↓, miR-194↑, NEAT1↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CYP4A/CYP4A11/CYP4A22↓, 1,   NEAT1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

FGF21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

miR-194↑, 1,  

Migration(tgid=13) ⓘ

TGF-β↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   mPGES-1↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CYP4A/CYP4A11/CYP4A22, Cytochrome P450 Family 4 Subfamily A
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1688  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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