NEAT1 Cancer Research Results

NEAT1, Nuclear Paraspeckle Assembly Transcript 1: Click to Expand ⟱
Source:
Type:

NEAT1 - Nuclear Paraspeckle Assembly Transcript 1

Type: Long non-coding RNA / paraspeckle structural RNA / transcriptional and post-transcriptional regulator

Function: NEAT1 is a nuclear long non-coding RNA and an essential structural component of paraspeckles. It acts as a molecular scaffold for RNA-binding proteins and regulates transcription, RNA processing, cellular stress responses, DNA-damage responses, epigenetic regulation, and gene expression. NEAT1 can also function as a competing endogenous RNA by sequestering specific microRNAs and altering expression of their downstream targets.

Cancer: ↑ Frequently overexpressed in solid tumors. Elevated NEAT1 promotes proliferation, survival, epithelial-mesenchymal transition, migration, invasion, metastasis, cancer stem-like properties, and resistance to anticancer therapy. NEAT1 can act through paraspeckle formation, interactions with epigenetic regulators such as EZH2, and miRNA-sponging mechanisms. Some hematologic malignancies show different behavior, so the effect remains tumor-type dependent.

Alzheimer's Disease: ↑ NEAT1 expression is frequently elevated in Alzheimer's disease and experimental AD models. Increased NEAT1 has been associated with amyloid-β accumulation, tau hyperphosphorylation, neuroinflammation, mitochondrial dysfunction, synaptic impairment, and neuronal injury through pathways involving miR-124, miR-107, BACE1, NF-κB, PINK1, and related signaling networks. Some NEAT1 responses may also represent stress-adaptive mechanisms, but the dominant reported disease-associated direction is increased.
Scientific Papers found: Click to Expand⟱
7749- ISL,    Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1
- in-vitro, GBM, U87MG
angioG↓, COX2/PTGS2↓, mPGES-1↓, CYP4A/CYP4A11/CYP4A22↓, FGF21↓, TGF-β↓, VEGF↓, miR-194↑, NEAT1↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CYP4A/CYP4A11/CYP4A22↓, 1,   NEAT1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

FGF21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

miR-194↑, 1,  

Migration(tgid=13) ⓘ

TGF-β↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   mPGES-1↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: NEAT1, Nuclear Paraspeckle Assembly Transcript 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1689  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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