AApath Cancer Research Results

AApath, Arachidonic Acid Pathway: Click to Expand ⟱
Source:
Type:

Arachidonic Acid Pathway - Arachidonic Acid Metabolism / Eicosanoid Pathway

Abbreviation: AA pathway, ARA pathway

Type: Lipid metabolic and inflammatory signaling pathway

Function: The arachidonic acid pathway generates a large family of bioactive eicosanoid signaling molecules. Arachidonic acid is released from membrane phospholipids primarily by phospholipase A2 (PLA2) and is subsequently metabolized through three major enzymatic branches: cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) pathways. These pathways generate prostaglandins, prostacyclin, thromboxanes, leukotrienes, lipoxins, HETEs, and EETs that regulate inflammation, vascular function, immune responses, proliferation, apoptosis, migration, and tissue homeostasis.

Cancer: ↑ / dysregulated. Increased arachidonic acid release and eicosanoid metabolism are common features of many cancers. Pro-tumor branches including COX-2/PGE2, 5-LOX/leukotriene signaling, 12-HETE, CYP4A/20-HETE, and selected CYP-derived EET pathways can promote proliferation, survival, angiogenesis, immune evasion, invasion, and metastasis. However, individual arachidonic acid metabolites can exert opposing effects, so specific enzymes and metabolites should be recorded separately whenever possible.
Scientific Papers found: Click to Expand⟱
7750- ISL,    Isoliquiritigenin in Breast Cancer: A Systematic Review of Its Preventive and Anti-metastatic Mechanisms
- Review, BC, NA
AntiCan↑, Apoptosis↑, TumAuto↑, mTOR↓, AApath↓, EMT↓, BRCA1↝, PI3K↓, Akt↓, angioG↓, VEGF↓, Hif1a↓, COX2/PTGS2↓, NF-kB↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AApath↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↝, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   mTOR↓, 1,   PI3K↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   NF-kB↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BRCA1↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: AApath, Arachidonic Acid Pathway
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1690  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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